Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth Cohort

摘要 CHAMACOS是一项纵向队列研究，研究对象是来自加州农场工人的拉丁裔母亲和儿童 已被跟踪超过20年的社区，以评估环境暴露的影响 以及影响儿童健康和发展的社会决定因素。CHAMACOS的母亲在 自1999-2000年怀孕以来，她们和她们的孩子经常被看到。过去两 几十年来，我们从这一群体中积累了丰富的行为、健康和暴露数据。我们积极 生物储存库容纳330，000个生物（如血液，尿液，母乳，头发，唾液，牙齿）和环境 我们将继续挖掘这些样本（如灰尘、过敏原），以获得环境健康方面的新见解。我们还持有 二十年来关于儿童神经发育，肺功能，身体发育，青春期时间， 心血管代谢健康、社会心理功能和精神健康。队列 目前由近600名母亲（第一代）和他们20-22岁的年轻成年子女（第二代）组成 他们中的一些人已经开始有自己的孩子（第三代）。我们提议开始 第三代参与者的数据收集，提供了一个前所未有的机会， 未来的资金，环境暴露和社会决定因素的多代表观遗传效应， 特征鲜明的拉丁裔群体 在上一个R24中，我们继续加强社区参与，这对保持 队列;促进新的研究伙伴关系;提高我们的数据共享能力，协议， 通过门户网站保持透明度;并保持一个强大的生物储藏库，随时准备解决新的 研究问题。在该项目的下一阶段，在U24下，我们将通过以下方式扩大这一重要工作： 用关于健康的社会决定因素的额外数据丰富我们的队列;为招募 CHAMACOS的第三代参与者;通过以下方式促进科学和劳动力多样性： 与西班牙裔服务机构和学生和临床医生从拉丁美洲农场工人的合作 社区.我们将扩大资源共享，通过开放获取使我们的数据公开， 数据储存库，并通过我们的门户网站促进生物和环境样本的共享。 此外，随着CHAMACOS创始人的退休，我们将把这一群体的领导权移交给 新一代的调查人员，以确保其持续，长期的成功。 这一群体代表着丰富的资源，应该在未来得到维护、丰富和共享。 研究机会。它有一个从事拉丁美洲参与人口，使科学洞察到一个 服务不足的人口，并提供机会，让年轻的拉丁裔学生，临床医生和初级 教师建立未来的环境健康研究人员的管道。

ABSTRACT CHAMACOS is a longitudinal cohort study of Latino mothers and children from a California farmworker community who have been followed for more than 20 years to assess the impact of environmental exposures and social determinants on children’s health and development. CHAMACOS mothers were enrolled during pregnancy in 1999-2000; they and their children have been seen regularly since then. Over the past two decades, we have amassed a rich trove of behavioral, health, and exposure data from this cohort. Our active biorepository houses 330,000 biological (e.g. blood, urine, breastmilk, hair, saliva, teeth) and environmental samples (e.g. dust, allergens) that we continue to mine for new insights in environmental health. We also hold two decades’ worth of data on children’s neurodevelopment, lung function, physical growth, pubertal timing, cardiometabolic health, and psychosocial functioning and mental health into young adulthood. The cohort currently consists of almost 600 mothers (1st generation) and their 20-22 year old young adult children (2nd generation), some of whom have begun to have children themselves (3rd generation). We propose to begin data collection on the 3rd generation of participants, providing an unprecedented opportunity to assess, under future funding, multigenerational epigenetic effects of environmental exposure and social determinants in a well-characterized Latino cohort. Under the previous R24, we continued our strong community engagement that is vital to retention of the cohort; facilitated new research partnerships; improved our data sharing capabilities, protocols, and transparency through a web-portal; and maintained a strong Biorepository that is poised to address new research questions. In the next phase of this project, under the U24, we will expand on this important work by enriching our cohort with additional data on social determinants of health; laying the groundwork to enroll the 3rd generation of CHAMACOS participants; and promoting scientific and workforce diversity through collaborations with Hispanic-Serving Institutions and students and clinicians from Latino farmworker communities. We will expand resource sharing by making our data publicly available through an open-access data repository and promote sharing of biological and environmental samples through our web portal. Additionally, as the CHAMACOS founders move into retirement, we will transfer the leadership of the cohort to a new generation of investigators to ensure its continued, long-term success. This cohort represents a wealth of resources that should be maintained, enriched, and shared for future research opportunities. It has an engaged Latino participant population that allows scientific insight into an underserved population and provides opportunities to engage young Latino students, clinicians, and junior faculty to build the pipeline of future environmental health researchers.