Endocrine disrupting and immune effects of Triclosan in children
三氯生对儿童的内分泌干扰和免疫影响
基本信息
- 批准号:9010955
- 负责人:
- 金额:$ 7.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-02-06 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:12 year old5 year old7 year old9 year oldAddressAdultAgeAllergicAmericanAnimalsAnti-Bacterial AgentsAntibiotic ResistanceAsthmaBiologicalBiological MarkersBirthBloodCD4 Positive T LymphocytesCaliforniaChemicalsChildChildhoodChildhood AsthmaClinicalCohort StudiesDataData AnalysesData SetDermalDevelopmentDiagnosisDoseEndocrineEndocrine DisruptorsEndocrine disruptionEndocrine systemEnvironmental ExposureExposure toFemaleFollicle Stimulating HormoneFoundationsFundingFutureGonadal Steroid HormonesGrowthHalf-LifeHandHealthHelper-Inducer T-LymphocyteHomeostasisHormonesHumanHypersensitivityIgEImmuneImmune systemIn VitroInfantIngestionLifeLinkLiquid substanceLong-Term EffectsLongitudinal StudiesLow incomeLuteinizing HormoneMeasurementMeasuresMedical RecordsMexican AmericansMothersMouthwashNational Health and Nutrition Examination SurveyNewborn InfantOutcomePerinatal ExposurePersonal CommunicationPhenolsPhysiciansPoliciesPregnancyPregnant WomenProspective StudiesPubertyReportingResearchRiskRodentSafetySalinumSamplingSchool-Age PopulationSoapsSpirometrySpottingsStagingSymptomsTestosteroneThyroid HormonesThyrotropinThyroxineTimeTimeLineToothpasteTriclosanUnited States Environmental Protection AgencyUnited States Food and Drug AdministrationUrineWorkabstractingantimicrobialbisphenol Aboyscohortcritical periodcytokineearly childhoodearly onsetestrogenicgirlshigh rewardhigh riskhuman datain uteromalemeetingsneonatepersonal care productsprenatalprospectivepubertal timingresponseurinary
项目摘要
DESCRIPTION (provided by applicant): Exposure to triclosan, an antibacterial agent used in soaps, toothpaste, and other personal care products, is widespread, with 75% of Americans having detectable levels in their bodies. In vitro and animal studies show that triclosan is an endocrine disruptor. In rodent studies, triclosan exposure during critical windows of development lowers levels of the thyroid hormone thyroxine (T4), increases allergic sensitivity and asthma-like response, decreases testosterone in males, and alters pubertal timing in females. To date, only a small number of studies have examined health effects of triclosan in humans, focusing on school-age children and adults. These studies provide some confirmation of effects on endocrine and immune systems, but they do not address exposure in utero - a critical period for endocrine disruption and immune development - and thus likely underestimate triclosan's potential health impact. Both the U.S. Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) are embarking on comprehensive regulatory reviews of triclosan, but are challenged by a dearth of human data. High-quality, independent research assessing associations of prenatal and early childhood triclosan exposures with subsequent health effects are urgently needed. The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) is a longitudinal birth cohort study that has gathered comprehensive data on environmental exposures, health, and development in more than 300 children who have participated from before birth through age 12. We propose to characterize urinary triclosan concentrations from CHAMACOS mothers during pregnancy and their children at 5 and 9 years of age and to examine the potential impact of this exposure on: 1) thyroid hormone homeostasis in pregnant women and newborns, 2) allergy and asthma symptoms in children at ages 5 and 7, and 3) timing of puberty and sex hormone levels in children between ages 9 and 12. We have already collected most of the data needed to achieve these aims, and crude, preliminary analyses suggest associations of triclosan with decreased T4 and increased risk of asthma symptoms in this cohort. However, the work needed to finalize urinary triclosan measurements, obtain additional outcome data, and conduct sophisticated data analyses that control for longitudinal effects and confounding cannot be completed without dedicated funding. This study is exploratory, because it is the first longitudinal study of developmental triclosan exposure; developmental, in that it lays groundwork for future in-depth research; and high risk, because we hope to have results in time to inform pending policy decisions. By relying on a rich existing data, this project can be completed in just two years, promising high regulatory and scientific impact.
描述(由申请人提供):暴露于Triclosan,这是一种用于肥皂,牙膏和其他个人护理产品的抗菌剂,是普遍存在的,其中75%的美国人的体内有可检测的水平。体外和动物研究表明,三氯生是一种内分泌破坏者。在啮齿动物的研究中,临界发育范围内的三氯生的暴露降低了甲状腺激素甲状腺素的水平(T4),增加了过敏敏感性和类似哮喘的反应,降低了男性的睾丸激素,并改变了女性的青春期时间。迄今为止,只有少数研究研究了三氯生对人类的健康影响,重点是学龄儿童和成人。这些研究提供了对内分泌和免疫系统的影响的一些确认,但它们不能解决子宫内的暴露 - 内分泌干扰和免疫发育的关键时期 - 因此可能低估了三氯糖的潜在健康影响。美国食品和药物管理局(FDA)和环境保护署(EPA)都在进行三氯生的全面监管审查,但受到人类数据的匮乏挑战。迫切需要高质量的独立研究评估产前和幼儿三氯一暴露与随后的健康影响的关联。 萨利纳(Chamacos)的母亲和子女的健康评估中心是一项纵向出生队列研究,在300多名从出生之前参与到12岁之前参与的儿童的环境暴露,健康和发育的全面数据。我们建议我们在5岁和9岁时的尿液中表现出5岁和9岁以下的三角体浓度:在5岁和9岁时,以下年龄在5岁时,以享年5岁,并在5岁时的儿童进行了5岁以下的孩子,并在5岁时的儿童进行了5年级的影响,并在5岁以下的儿童中进行了5岁以下年龄,并在5岁时享受。 thyroid hormone homeostasis in pregnant women and newborns, 2) allergy and asthma symptoms in children at ages 5 and 7, and 3) timing of puberty and sex hormone levels in children between ages 9 and 12. We have already collected most of the data needed to achieve these aims, and crude, preliminary analyses suggest associations of triclosan with decreased T4 and increased risk of asthma symptoms in this队列。但是,最终确定尿三氯生测量,获取其他结果数据并进行复杂的数据分析所需的工作,没有专门的资金就无法完成控制纵向效应和混淆的复杂数据分析。 这项研究是探索性的,因为它是对发育三氯生的首次纵向研究。发展性,因为它为未来的深入研究奠定了基础;和高风险,因为我们希望能有时间为未决的政策决定提供信息。通过依靠丰富的现有数据,该项目可以在短短两年内完成,并有望产生高监管和科学影响。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study.
- DOI:10.1038/s41370-017-0003-z
- 发表时间:2019-01
- 期刊:
- 影响因子:4.5
- 作者:Berger KP;Kogut KR;Bradman A;She J;Gavin Q;Zahedi R;Parra KL;Harley KG
- 通讯作者:Harley KG
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Kim G. Harley其他文献
Kim G. Harley的其他文献
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{{ truncateString('Kim G. Harley', 18)}}的其他基金
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth Cohort
通过维持和丰富 CHAMACOS 出生队列来促进科学和劳动力多样性
- 批准号:
10588835 - 财政年份:2017
- 资助金额:
$ 7.8万 - 项目类别:
Endocrine disrupting and immune effects of Triclosan in children
三氯生对儿童的内分泌干扰和免疫影响
- 批准号:
8806355 - 财政年份:2015
- 资助金额:
$ 7.8万 - 项目类别:
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