Administrative Supplement to Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

摘要 静脉血栓栓塞症(VTE)是美国第三常见的心血管疾病。 静脉停滞可在长时间不活动期间发生，是VTE的已知危险因素；然而， 体力活动与VTE的关系不一致，体力活动后的指导 缺少一支VTE。这项拟议的“行政补编”的总体目标是 保留NIH导师职业发展(K)奖获得者和学者 对NHLBI资助的K01的科学和训练目标的补充支持，“身体活动，久坐 行为和静脉血栓栓塞症风险“，在一次生活事件之后。劳拉·B·哈林顿博士的继父 K01奖项旨在加深我们对身体活动和久坐行为的了解：(1) 事件VTE风险，(2)体力活动后的短期VTE风险，(3) 事件VTE；(4)与血栓事件风险相关的止血因子水平。本研究 利用妇女健康倡议和护士健康研究I和II队列的现有数据 除了在病例交叉研究的背景下新收集数据。建议的创新方面 工作包括评估加速计测量的身体活动和与以下方面有关的久坐行为 VTE风险，使用病例交叉方法评估体力活动后VTE风险， 评估VTE幸存者的体力活动和久坐行为与长期预后的关系，以及 与止血参数测量相关的日常体力活动的评估。不仅是提议的 的科学目标

Summary Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States. Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however, the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after a VTE is lacking. The overarching goal of this proposed “Administrative Supplement for Continuity and Retention of NIH Mentored Career Development (K) Award Recipients and Scholars” is to provide supplemental support of the scientific and training aims of the NHLBI-funded K01, “Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk”, following a life event. Dr. Laura B. Harrington's ongoing parent K01 award aims to further our understanding of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor levels, which are associated with thrombotic event risk. This study leverages existing data from the Women's Health Initiative and the Nurses' Health Studies I and II cohorts in addition to newly collecting data in the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE risk following physical activity using case-crossover methodology, the evaluation of physical activity and sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of