Core C Molecular Informatics Core

摘要 分子信息学核心 分子信息学模块将提供蛋白质组和代谢组/同位素研究战略方面的援助。 并向参与P30科尔视力研究核心的研究人员介绍相关技术。开发所需的时间 蛋白质组和代谢组学技术方面的专业知识经常给有能力的研究人员带来研究障碍 其他专业技能。具体地说，该模块将提供1)实验设计咨询、技术支持和 对正常和疾病眼组织和细胞系统进行全球和靶向蛋白质定量的数据分析，包括 蛋白质组生物信息学；2)蛋白质组研究战略和视觉科学技术支持的集中资源 涉及蛋白质鉴定、蛋白质相互作用和翻译后修饰的研究；3)实验 正常和疾病眼组织和细胞系统代谢组谱的设计咨询和技术支持； 和4)代谢组研究战略和视觉科学研究技术支持的集中资源，包括 代谢生物信息学。该核心模块将支持NEI R01资助的调查人员，帮助新招聘的 调查人员为NEI R01拨款申请获取数据，促进RO1资助的调查人员之间的协作互动 和新招聘的调查人员，吸引其他部门的调查人员来研究视觉系统，并成为 在我们扩大研究人员的同时，吸引更多的视觉科学家加入我们的项目，这是宝贵的部门资源。

Abstract Molecular Informatics Core The Molecular Informatics Module will provide assistance with proteomic and metabolomic/isotopomic research strategies and technologies to the investigators involved in this P30 Cole Eye Vision Research Core. The time required to develop expertise in proteomic and metabolomic technologies often generates research roadblocks to capable investigators with other specialized skills. Specifically, the module will provide 1) experimental design consultation, technical support, and data analysis for global and targeted protein quantitation in normal and diseased ocular tissues and cell systems, including proteomic bioinformatics; 2) a centralized resource for proteomic research strategy and technical support for vision science studies involving protein identification, protein-protein interactions and posttranslational modifications; 3) experimental design consultation and technical support for metabolomic profiling in normal and diseased ocular tissues and cell systems; and 4) a centralized resource for metabolomic research strategy and technical support for vision science studies, including metabolomic bioinformatics. This core module will support NEI R01-funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1-funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.