Admin Core

项目总结 人类疾病计算生物学(CBHD)第二阶段的目标是加强、扩展、 并支持专注于人类疾病基础生物学计算方法的研究项目。 这涉及到支持教员调查人员，以增加他们对同行审查资金的竞争力，因为 以及对资源和基础设施的支持，以加强布朗更广泛的生物医学研究社区。 该中心的一个关键主题是建立在生物医学研究人员的优势之上，他们的个人问题 可能有很大的不同，但他们的基本分析问题在计算分析中有共同点 导致发现的大规模基因组数据集。行政核心将领导、协调和 1)管理中心的一般活动，包括战略规划、咨询委员会会议、财务 问责制、合规、沟通和报告；2)职业发展活动 初级调查人员，包括研究项目和试点项目计划、指导活动和 计算生物学核心资源，以及3)加强计划可持续性的活动，包括战略 合作伙伴关系、项目整合、社区建设、项目评估和成本中心规划。这个 第二阶段的管理核心将建立在 第一阶段，已被证明有效。布朗大学在生成数据的设施上投入了大量资金(例如， 基因组学核心)，即维护超级计算机的计算和可视化中心(CCV 并为支持高性能计算和研究的高级研究计算小组提供工作人员 以生物学和医学为目标的学术兴趣中心。我们的CBHD Cobre与研究截然不同 中心作为唯一的服务中心，专注于分析启用组学的数据。我们将实现以下目标 在第二阶段加强和维持科布雷，具体目标如下。1.提供科学的 领导、行政协调和财政管理，以支持继续整合、扩大 和加强该中心的力量。2.为初级教员项目负责人提供研究资金、职业生涯 开发指导和计算资源，以加强研究竞争力并实现 同行评审、可持续资助的研究项目。3.促进和确保中心的可持续性和 通过综合社区建设、建立战略协作伙伴关系和 对形成性和终结性项目评估做出回应。

PROJECT SUMMARY The goal of this Phase 2 COBRE for Computational Biology of Human Disease (CBHD) is to strengthen, expand, and sustain research programs focusing on computational approaches to the basic biology of human diseases. This involves support for faculty investigators that increases their competitiveness for peer-reviewed funding, as well as support for resources and infrastructure that enhances Brown’s broader biomedical research community. A key theme of this Center is to build upon the strengths of biomedical researchers whose individual questions may differ widely, but whose underlying analytical questions share common ground in computational analyses of large-scale genomic datasets that lead to discovery. The Administrative Core will lead, coordinate, and manage 1) the general activities of the Center including strategic planning, advisory committee meetings, fiscal accountability, regulatory compliance, communication, and reporting; 2) the career development activities of the junior investigators including the Research Projects and Pilot Project programs, mentoring activities, and the Computational Biology Core resource, and 3) activities that strengthen program sustainability including strategic partnerships, program integration, community building, program evaluation, and cost-center planning. The Administrative Core in Phase 2 will build upon the resources and infrastructure developed and implemented in Phase 1 with proven effectiveness. Brown University has invested heavily in facilities that generate data (e.g., the Genomics Core), the Center for Computation and Visualization (CCV) that maintains the super computer and staffs the Advanced Research Computing group that supports high performance computing, and research centers with targeted academic interests in biology and medicine. Our CBHD COBRE is distinct from research centers as the sole service Center focused on analysis of omics-enabled data. We will achieve the goals of strengthening and sustaining the COBRE in Phase 2 with the following Specific Aims. 1. Provide scientific leadership, administrative coordination, and fiscal management to support the continued integration, expansion and strengthening of the Center. 2. Provide junior faculty Project Leaders with research funding, career development mentoring, and computational resources to strengthen research competitiveness and achieve peer-reviewed, sustainably funded research programs. 3. Facilitate and ensure Center sustainability and responsiveness by integrative community building, establishing strategic collaborative partnerships, and responding to formative and summative program evaluation.