The Institute for Biomolecular Targeting

达特茅斯生物分子靶向研究所(BioMT)为机械研究注入了一种 对疾病病理和治疗需求的复杂认识，甚至提高了大多数 基础研究。同时，它有助于将机械性调查向长期方向发展。 针对癌症和感染等复杂疾病的翻译目标。在第一阶段，我们的进展是强劲的。 我们的六位研究项目负责人(RPL)都获得了超过两年的支持，获得了R01同等资质 资金问题。我们的核心提供了独特的蛋白质生物化学资源和访问显微镜的“导航器” 全校范围内。我们的核心和研讨会创造了一个充满活力的跨学科社区。在这里，我们 建议部署第二阶段Cobre和机构方案充实基金，以此为基础并 填补关键空白，为向可持续的科布雷独立过渡做好BioMT准备。目标1是增加我们的 一批受资助的生物MT研究人员，以填补我们研究版图中的战略角色。我们最近的两个 RPLS(3-15个月的支持)将继续进入第二阶段，同时还有两名优秀的新员工加入。他们的项目 探索与治疗靶点范围潜在相关的基本信号和免疫学机制 从呼吸道感染到癌症进展和转移，通过共享的科学和 技术利益。所有人都接受专门的指导二人组的指导，以帮助职业发展和 独立的外部资金，所有的都得到了响应的科学核心的支持，提供了最新的- 与他们的生物转基因研究项目直接相关的ART技术。在机构支持下，我们还将招聘 五名新的教员，与我们发现和利用分子靶标的主题一致，以及 被选中以加强专题分组。随着RPL的毕业，我们将招聘新员工和其他人员 选管会考虑的潜在继任者。目标二是加强我们的核心设施和 为他们在第三阶段过渡到Cobre独立做好准备。核心人员配备齐全，并具有 在第一阶段仪器设备上投入了大量资金。我们将合作添加基于用户输入的关键新技术， 包括平行蛋白质表达、质谱学、高级显微镜和低温电子显微镜。收回成本 将制定在第三阶段逐步部署的模型，以实现核心财务独立。目标 3继续丰富我们的社区，包括小型研讨会和试点奖项，以培养新的多元PI和 方案-项目应用，这将有助于核心可持续性。总体而言，这些目标将对 久经考验的Cobre战略-初级教师招聘、校外和学术指导、出色的行政管理 和科学核心支持，以及跨学科社区建设--以增强生物技术在 有针对性的需求领域。这将为我们过渡到第三阶段资金和最终独立做好准备。 作为一个跨学科和全国可见的研究机构，横跨三个学院和10个系，位于 达特茅斯，与当地中心和地区创意合作伙伴建立了密切的联系。

The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards long-term translational goals for complex diseases such as cancer and infections. In phase I, our progress was strong. All six of our research project leaders (RPL) with more than two years’ support have received R01-equivalent funding. Our cores provide unique protein biochemistry resources and ‘navigators’ to access microscopes campus-wide. Our cores and seminars have created a vibrant and interdisciplinary community. Here, we propose to deploy phase II COBRE and institutional program enrichment funds to build on this foundation and fill key gaps to prepare bioMT for the transition to sustainable COBRE independence. Aim 1 is to increase our cohort of funded bioMT investigators to fill strategic roles in our research landscape. Our two most recent RPLs (3–15 months’ support) are continuing into phase II, joined by two outstanding new hires. Their projects explore basic signaling and immunological mechanisms with potential relevance to therapeutic targets ranging from respiratory infections to cancer progression and metastasis, interconnected by shared scientific and technical interests. All receive guidance from dedicated mentoring dyads to assist in career advancement and independent extramural funding, and all receive support from responsive scientific cores offering state-of-the- art technologies directly relevant to their bioMT research projects. With institutional support, we will also hire five new faculty members, aligned with our theme of discovering and exploiting molecular targets, and selected to enhance thematic subgroups. As starting RPLs graduate, we will recruit new hires and other potential candidates for EAC consideration as replacements. Aim 2 is to enhance our core facilities and prepare them for a transition to COBRE independence during phase III. The cores are fully staffed and have invested heavily in phase I instrumentation. We will partner to add key new technologies based on user input, including parallel protein expression, mass spectrometry, advanced microscopy, and cryoEM. Cost-recovery models will be developed for incremental deployment in phase III to enable core financial independence. Aim 3 continues enriching our community, including mini-symposia and pilot awards to foster new multi-PI and program-project applications, which will contribute to core sustainability. Overall, these aims will leverage proven COBRE strategies – junior faculty hiring, extramural and academic mentoring, excellent administrative and scientific core support, and interdisciplinary community building – to enhance bioMT’s scientific impact in targeted areas of need. This will prepare us for the transition to phase III funding and ultimate independence as an interdisciplinary and nationally visible research institute, spanning three schools and 10 departments at Dartmouth and deeply connected to local centers and regional IDeA partners.