2/2 Howard-Georgetown Collaborative Partnership in Cancer Research

总体摘要 NCI Collaborative P20 Partnership in Cancer Research 的总体目标是增强癌症研究能力 霍华德大学的研究能力，并增加对癌症健康差异研究的参与 乔治城隆巴迪综合癌症中心 (GU)。伙伴关系的目标将通过以下方式实现 两个主要机制：试点研究项目和癌症研究教育。 P20将受益于 由高素质、经验丰富的科学家组成的内部咨询委员会 (IAC) 的指导。的 研究试点项目将资助四个为期两年的合作研究试点项目。每个项目将包括 至少一名来自霍华德的调查员和一名来自乔治城的调查员。研究人员将从 HU/GU 中受益 CTSA 和 GU 提供的共享资源。试点项目1将确定候选基因和遗传 与非酒精性脂肪肝（NAFLD）相关的途径。该研究将告知可能 代谢和机械紊乱的分子和遗传特征背后的生物机制 非裔美国人人群 NAFLD 患者的通路。结果可能会带来创新的非侵入性 生物标志物。研究项目 2 将调查慢性压力、生活质量和身体活动方面的差异 黑人和白人乳腺癌幸存者中。这项研究将深入了解是否存在关联 乳腺癌幸存者的体力活动和稳态负荷之间的关系。在颁奖过程中，P20 合作伙伴关系将通过竞争性过程引发两项额外的试点研究，该过程将由优点驱动 由 IAC 审查。试点项目的预期成果是成功提交合作资助 通过试点研究获得的初步数据支持应用。 C-REP 将致力于 通过让代表性不足的多元化学生和教师参与进来，实现合作伙伴关系的目标 生物医学研究的研究者。由大三或大四的大学生组成的群体 每年，研究生和专业学生将被招募参加为期 8 周的夏季强化辅导 研究经验。将提供后续指导，以促进毕业生或专业人士的进入 计划或博士后研究培训。博士后研究员和教师将接受培训和指导 支持获得稳健、高质量的出版记录并提交极具竞争力的独立论文 研究建议。 C-REP 内的指导将通过至少由来自双方的一名教职人员组成的团队进行 机构。霍华德-乔治城 P20 合作伙伴关系带来了许多优势，包括大量的欠缺人才 代表霍华德大学的学生和教师，通过 GU 提供广泛的研究资源，以及 为两个机构之间长期、富有成效的伙伴关系奠定了基础。

Overall Abstract The overarching goal of the NCI Collaborative P20 Partnership in Cancer Research is to enhance cancer research capacity at Howard University and increase participation in cancer health disparities research at Georgetown Lombardi Comprehensive Cancer Center (GU). The Partnership goals will be achieved through two primary mechanisms: pilot research projects and cancer research education. The P20 will benefit from the guidance of an Internal Advisory Committee (IAC) made up of highly qualified and experienced scientists. The Research Pilot Projects will fund four 2-year collaborative research pilot projects. Each project will include at least one investigator from Howard and one from Georgetown. The investigators will benefit from the HU/GU CTSA and the Shared Resources available at GU. Pilot project 1 will identify candidate genes and genetic pathways associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The research will inform possible biological mechanisms underlying the molecular and genetic signatures of perturbed metabolic and mechanistic pathways in NAFLD patients in an African–American population. Results may lead to innovative non-invasive biomarkers. Research Project 2 will investigate disparities in chronic stress, quality of life, and physical activity among Black and White breast cancer survivors. This study will provide insight into whether an association exists between physical activity and allostatic load in breast cancer survivors. During the course of the award, the P20 Partnership will elicit two additional pilot studies through a competitive process which will be driven by a merit review by the IAC. The expected outcome of the pilot projects is the submission of successful collaborative grant applications supported by the preliminary data obtained via the pilot research. The C-REP will contribute to the goals of the Partnership by engaging a diverse group students and faculty who are under-represented as investigators in biomedical research. A cohort consisting of a mix of college students in their junior or senior year, graduate and professional students will be recruited annually for an intensive 8-week mentored summer research experience. Follow-up mentoring will be provided to promote entry into a graduate or professional program or postdoctoral research training. Postdoctoral fellows and faculty will receive training and mentoring to support attaining a robust, high quality publication record and submission of highly competitive independent research proposals. Mentoring within the C-REP will occur via teams of at least one faculty member from both institutions. The Howard-Georgetown P20 Partnership brings many strengths including a large pool of under- represented students and faculty at Howard University, extensive research resources through GU, and a foundation of longstanding, productive partnerships between the two institutions.