Center of Biomedical Research Excellence in Pathogen Host Interactions

抽象行政核心（核心A） 核心A的作用是通过实现以下目标来实现总体部分中确定的目标（具体目标）： 以下具体目标：1）通过增加新的 在第一阶段取得成功的科学家。2)监测研究者里程碑并分享 向调查人员和领导团队提供信息。3)协调指导活动和互动 与内部和外部导师和外部咨询委员会。这包括立即规划 每个研究员的R01申请。4)建立并维护第一阶段和 第二阶段调查人员将加强现有的合作，并促进独立调查的发展。 研究团体。5)管理可持续的技术核心，以支持生物医学的持续增长 研究企业在密歇根州立大学，并报告给PI。和领导团队的使用和有效性， 丹6)与赞助项目办公室（OSP）合作管理COBRE的财务方面， 参与COBRE的学院和部门的财务官员，并维护COBRE网站， 协调外联活动。为实现这些目标，提出了具体计划。在 此外，调查员服务和外联活动将集中在核心A。研究者服务包括 由我们最成功的第1阶段研究者个人协助准备赠款申请。还 科学插画家将提供服务，为您准备有效的、教科书质量的插图， 手稿和赠款申请。同一个人也是一个专家网页设计师，并将负责 我们的COBRE网站，这将是我们的推广工作的一个主要组成部分。另一项调查服务 将是每个项目的每月财务预测。在第一阶段的第四年，COBRE结束了赠款 今年，只有1.69%的原始资金剩余。这是可能的，因为调查人员收到了 定期反馈和提醒他们在赠款年度期间的支出率。这将 继续第二阶段。指导是管理核心和COBRE业务经理的关键角色 将在COBRE定期会议（每月研讨会、每月工作会议、 进度会议，每月与外部和内部导师联系，每年参加COBRE 外部咨询委员会和所有导师参加的研讨会）。这是一个里程碑， 第二阶段资助机会公告是提交一个主要的研究项目资助（RPG）的结束 第二年融资。这会被仔细监控，私家侦探导师和领导团队 一旦获得资助，COBRE将开始与每位研究人员合作， R01应用程序具有充足的初步数据。其中包括处理未能达到里程碑的机制， 但在私家侦探中作为部门负责人，他发现设定高期望值和保持 积极的态度可以有效地说服调查人员提高自己的期望和表现。

Abstract Administrative Core (Core A) The role of Core A is to implement the goals (Specific Aims) identified in the Overall Section by achieving the following Specific Aims: 1) Improve the Administrative Core developed in Phase I by addition of new scientific personnel who were successful in Phase I. 2) Monitor investigator milestones and share this information with the investigators and the leadership team. 3) Coordinate mentoring activities and interactions with internal and external mentors and the External Advisory Committee. This includes immediate planning for an R01 application for each Investigator. 4) Establish and maintain communication between Phase I and Phase II investigators to enhance collaborations that already exist and promote development of independent research groups. 5) Manage sustainable Technical Cores to support continued growth of the biomedical research enterprise at MSU, and report to the P.I. and leadership team on the usage and effectiveness of the Cores. 6) Manage fiscal aspects of the COBRE in partnership with the Office of Sponsored Projects (OSP) and fiscal officers in the colleges and departments involved in the COBRE and maintain the COBRE web site and coordinate outreach activities. Specific plans are presented to allow each of these aims to be achieved. In addition, investigator services and outreach activities will be centered in Core A. Investigator services include individual assistance in preparing grant applications by our most successful Phase 1 investigator. Also, the services of a scientific illustrator will be available for preparing effective, textbook quality illustrations for manuscripts and grant applications. The same individual is also an expert web designer, and will be in charge of our COBRE Web Site, which will be a major component of our outreach efforts. Another investigator service will be monthly financial projections for each project. During Year 4 of Phase I, the COBRE ended the grant year with only 1.69% of the original funds remaining. This was possible only because investigators received regular feedback and reminders regarding their rate of spending during the course of the grant year. This will continue in Phase II. Mentoring is a key role for the Administrative Core, and the COBRE Business manager will monitor milestones and attendance at regular COBRE meetings (a monthly seminar, a monthly work-in- progress meeting, monthly contact with external and internal mentors and yearly participation in a COBRE Symposium attended by the External Advisory Committee and all mentors). A milestone that is stated in the Phase II Funding Opportunity Announcement is submitting a major Research Project Grant (RPG) by the end of the second year of funding. This will be monitored carefully, and the P.I., mentors, and the leadership team of the COBRE will begin working with each investigator as soon as the grant is funded to develop a competitive R01 application with ample preliminary data. Mechanisms to address failure to meet milestones are included, but in the P.I.’s role as department head, he has found that setting high expectations and maintaining a positive attitude can effectively persuade investigators to raise their own expectations and performance.