QMRA IV- Quantitative Microbial Risk Assessment Interdisciplinary Vehicle: Addressing Emerging Global Health Risks

项目总结/摘要 定量微生物风险评估（QMRA）是一个研究领域， 病原体和传染病过程，以确定对人类健康的影响。它已成为一个 健康风险预测和回顾性评估的完善框架。QMRA是一种翻译 需要整合数学、统计学、生物学、工程学和公共科学知识的科学 健康虽然复杂，QMRA是非常有用的解决社会问题中遇到的， 多学科生物医学界-公共卫生、应急反应、环境控制措施， 净化、工业卫生和医疗对策。接触致病微生物 和随后的感染发展是与实质性变异相关的动态过程， 这是一个非常复杂的问题，它涉及整个人群的不确定性，也必须进行沟通，以有效管理风险。以来 风险科学本质上是跨学科的，贡献学科中很少有项目提供课程， 在QMRA培训。虽然由于我们的初步工作，培训、模型和工具有所增加， 生物医学界充分参与的障碍仍然存在，特别是在指导和 外展我们的长期目标是提高生物医学和行为科学家的能力： 纳入并促进与其研究有关的微生物风险评估;以及（ii）增加其 能够领导和促进与微生物风险相关的多元化，跨学科团队科学项目。的 该项目的目标是为生物医学界提供微生物风险方面的全面培训 科学、循证指导方法，以支持科学家的包容和参与 不同的背景和数据/计算平台，以促进更深入的学习和QMRA实践。 拟议的项目建立在几个成功的，通过NIH资助的10天课程提供的基础上。 QMRAIII计划（2014年至2018年）和以前的一个为期一周的密集课程，通过 2006年至2011年，推进微生物风险评估中心）。每一年， 申请人比允许入学;和中期职业生涯和高级教师一般被排除在外， 优先考虑早期职业研究人员。我们的评价和评估支持我们的实践模式， 达到学习目标。然而，整个生物医学界的贡献平衡将是 通过持续的辅导和外联机会大大加强， 课程，以及为未来的学员和教育工作者的在线平台。

Project Summary/Abstract Quantitative microbial risk assessment (QMRA) is a research domain that addresses exposures to microbial pathogens and infectious disease processes in order to characterize human health effects. It has become a well-established framework for predictive and retrospective evaluations of health risks. QMRA is a translational science requiring integration of knowledge from mathematics, statistics, biology, engineering, and public health. Though complex, QMRA is highly useful for addressing societal problems encountered within the multidisciplinary biomedical community - public health, emergency response, environmental control measures, decontamination, industrial hygiene and medical countermeasures. Exposure to microbial agents of disease and subsequent development of infection are dynamic processes associated with substantial variability and uncertainty across the population, which must also be communicated in order to effectively manage risk. Since risk science is inherently interdisciplinary, few programs in the contributing disciplines offer courses and training in QMRA. Though training, models and tools have increased as the result of our preliminary work, barriers to full participation across the biomedical community still exists especially needs in mentoring and outreach. Our long term goals are to increase the capability for biomedical and behavioral scientists: (i) to incorporate and contribute to microbial risk assessments related to their research; and (ii) to increase their ability to lead and contribute to diverse, interdisciplinary team science projects related to microbial risks. The objective of this project is to provide the biomedical community with comprehensive training in microbial risk sciences, evidence-based mentoring approaches to support inclusion and participation of scientists from diverse backgrounds and a data/computational platform to facilitate deeper learning and the QMRA practice. The proposed project builds upon several, successful, ten-day courses offered through the NIH funded QMRAIII program (2014 to 2018) and previous one week-long, intensive courses conducted through the Center for Advancing Microbial Risk Assessment) from 2006 to 2011. Each year, there were significantly more applicants than allowable enrollment; and mid-career and senior faculty members were generally excluded to prioritize early career researchers. Our evaluations and assessments support our model of practice for reaching learning objectives. However, the balance of contributions across the biomedical community would be greatly enhanced through sustained mentoring and outreach opportunities which are complementary to the course as well as an online platform for future trainees and educators.