Postdoctoral Training for Translating Research in Regenerative Medicine

项目总结/摘要 目前的NIBIB T32博士后培训计划，“培训无国界：翻译研究， 《再生医学》（2012-2017），集中了两个创新特征：（1） 地理上分散的培训教师，以利用一个独特的导师团队;（2）结合 传统的学术培训（最先进的科学，提案写作，负责任的研究行为） 以及翻译和商业化方面的培训。这导致了地理上分散的 “学习社区”。该计划的核心优势是其跨学科的广度，提供 有机会对合理设计的生物材料、生物活性材料和生物相容性材料进行研究的学员 微环境、细胞分析技术和再生生物学。 基于这一成功，拟议的培训计划（2018-2023年）将保留目前的结构，修改 导师机构网络，并使用一个新的范例-从实验室到企业再到临床（B3）。而术语 从工作台到床边通常被用来描述翻译，我们认为B3模式提供了更相关的 通过为学员提供由学术、工业和 临床主题专家。除了专注于最先进的科学，博士后培训 项目必须提高受训人员在所有部门找到工作的机会：学术界， 行业，和替代的职业道路，以最终实现临床治疗。 我们创造了“创新驱动的科学”这个术语，来代表一系列的突破，创新- 产生科学的想法，这将为我们的学员提供一系列科学项目的工作，从开拓 从基础科学到准备商业化的项目，这些项目的概念验证已经建立。 我们将创建一个独特的培训基础设施，不仅由传统的学术导师组成 （领导顶级实验室的科学或临床教师），但也有翻译咨询委员会（TAB） 包括再生医学和临床实践专家，企业家，工业科学家， 投资者以及翻译和商业化领域的领先专家。TAB将有效填充 我们的学术教师导师之间的专业知识差距，通过完成学术， 工业和临床专家。 一个丰富的教学计划将结合联合收割机既建立方法和新的概念，以提供一个平衡， 同时优化14名核心导师和16名临床、工业和 创业顾问具体的计划要素包括个性化B3指导星座、面对面 面对面互动和研讨会，在线互动和研讨会系列，定义和分类集成 在奖学金期间的教学元素，指导学员和专业发展， 支持初级导师。

Project Summary/Abstract The current NIBIB T32 postdoctoral training program, "Training Without Borders: Translational Research in Regenerative Medicine" (2012-2017), has focused on two innovative features: (1) the concept of a geographically dispersed training faculty to harness a unique team of mentors; and (2) a combination of conventional academic training (state-of-the-art science, proposal writing, responsible conduct of research) together with training in translation and commercialization. This has resulted in a geographically dispersed "community of learning". The core strength of this program has been its interdisciplinary breadth, providing trainees with opportunities to conduct research on rationally designed biomaterials, bioactive microenvironments, cell profiling technologies, and regenerative biology. Based on this success the proposed training program (2018-2023) will retain the current structure, revise the mentor-institution network, and use a new paradigm - Bench-to-Business-to-Bedside (B3). While the term Bench-to-Bedside is often used to describe translation, we believe that the B3 model offers more relevant training in translation by providing trainees with mentoring constellations consisting of academic, industrial, and clinical subject matter experts. In addition to focusing on state-of-the-art science, postdoctoral training programs must improve the chances of their trainees finding employment across all sectors: academia, industry, and alternative career paths, in order to ultimately achieve clinical therapies. We have coined the term "innovation-primed science" to represent a range of breakthrough, innovation- generating scientific ideas that will offer our trainees a range of scientific projects to work on, from pioneering basic science to commercialization-ready projects, for which proof-of-concept has already been established. We will create a unique training infrastructure that is made up not only of the traditional academic mentors (scientific or clinical faculty who lead top laboratories), but also of a Translation Advisory Board (TAB) comprising experts in regenerative medicine and clinical practice, entrepreneurs, industrial scientists, investors, and leading subject-matter experts in translation and commercialization. The TAB will effectively fill the expertise gap among our academic faculty mentors, by completing a mentoring constellation of academic, industrial, and clinical experts for each trainee. A rich didactic program will combine both established approaches and new concepts to deliver a balance of experience to trainees while optimizing the expertise of 14 core mentors and 16 clinical, industrial and entrepreneurial advisors. Specific program elements are Individualized B3 Mentoring Constellations, Face-to- Face Interactions and Workshops, Online Interactions and Seminar Series, Defined and Monitored Integration of Didactic Elements during the Fellowship Term, Mentoring of Trainees and Professional Development, and Supporting Junior Mentors.