Synaptic plasticity in sensory learning

摘要 经验依赖性可塑性是新皮层的典型特征，在感觉和神经系统中都可以观察到。 运动学习以及更复杂的认知操作，如工作记忆。的 细胞类型和跨脑区突触连接的显著保守性表明， 可能是新皮层回路促进经验依赖性突触的一般原则， 与学习相关的修改。我们将检验这样一个假设，即接触新奇的事物， 感觉输入启动了一个共同的程序的细胞类型和输入特定的可塑性在整个皮层 列，而不管这些更改是否是行为更改所必需的。这些协作 研究将解决和解决学习领域的重要争议。

ABSTRACT Experience-dependent plasticity is a canonical feature of the neocortex, observed in both sensory and motor learning as well as more sophisticated cognitive operations such as working memory. The remarkable conservation of cell types and synaptic connectivity across brain areas suggests that there may be general principles by which neocortical circuits facilitate experience-dependent synaptic modifications relevant for learning. We will test the hypothesis that exposure to novel and rewarded sensory inputs initiates a common program of cell-type and input-specific plasticity across the cortical column, irrespective of whether these changes are required for behavioral change. These collaborative studies will address and resolve important controversies in the field of learning.