Integration of a multi-pronged standardized methodology to identify key diseases and prioritized antimicrobial alternatives in production animals

项目摘要 抗生素耐药性（AMR）被认为是对动物健康的重大威胁， 人类和植物，导致呼吁改善所有部门的抗菌剂管理。为了 为确保有限资源得到最佳利用，迫切需要确定 疾病和相关的替代策略，如果实施，将带来最大的 对改善抗菌药物管理的影响。本提案旨在弥补这一关键差距 采用整合循证和决策方法的方法， 范围审查、结构化的专家邀请（在某些情况下由专有的大型 规模数据和经验），以及四种牲畜的多标准决策分析（MCDA） 组这种方法提供了一个全面、系统和透明的框架， 确定并优先考虑最重要的疾病，然后是最有希望的替代方案 减少食用动物使用医学上重要的抗菌剂的方法， 保持动物的健康和福祉。该项目的重要性在于，相比之下， 就目前情况而言，该项目的顺利完成将产生全面的， 对疾病驱动因素的细致评估以及关于如何减轻 在鸡、肉牛、奶牛和猪中的抗微生物用途。这种综合方法， 结合应用于四个主要的食品生产物种，允许一致的， 解决FDA在本PAR中概述的具体需求的创新方法。这一努力 将由国家抗菌素耐药性研究和教育研究所领导 （NIAMRRE），一个成员组织，促进跨部门参与，以打击 AMR提出的挑战，与RTI国际合作，一个非营利研究 研究所在范围界定审查、专家启发和多标准决策分析方面具有专门知识。 NIAMRRE的专业知识包括来自四个主要领域的研究人员和主题专家 在动物健康和畜牧业生产方面拥有深厚专业知识的农业研究型大学： 加州戴维斯大学（奶牛领先）、俄亥俄州州立大学（肉牛领先）、 格鲁吉亚大学（肉鸡铅）和爱荷华州州立大学（猪铅）。总的来说， 这个团队为成功完成项目提供了出色的环境。的 这一框架的结果是，将在四个主要领域采用一致的方法， 牲畜物种，导致一致的战略建议沟通， 减少对医学上重要的抗菌剂的依赖。

PROJECT SUMMARY Antimicrobial resistance (AMR) is recognized as a significant threat to the health of animals, humans and plants, leading to calls to improve antimicrobial stewardship in all sectors. In order to assure the best utilization of limited resources, there is a critical need to identify the diseases and associated alternative strategies that, if implemented, would lead to the greatest impact on improving antimicrobial stewardship. This proposal seeks to address this critical gap with an approach that integrates evidence-based and decision-making methods such as scoping reviews, structured expert elicitations (informed in some cases by proprietary large- scale data and experience), and multi-criteria decision analysis (MCDA) across four livestock groups. This approach provides a comprehensive, systematic, and transparent framework to identify and prioritize the most important disease, and then the most promising alternative approaches to reduce the use of medically important antimicrobials in food animals, while maintaining animal health and wellbeing. The proposed project is significant in that, in contrast to the present situation, successful completion of the project will generate comprehensive and nuanced assessments of the disease drivers and recommendations on how to mitigate antimicrobial use in chickens, beef cattle, dairy cattle and swine. This integrated methodology, combined with application to four major food producing species, allows for a consistent and innovative approach to addressing the specific needs outlined by FDA in this PAR. This effort will be led by the National Institute of Antimicrobial Resistance Research and Education (NIAMRRE), a member organization that fosters cross-sector engagement to combat the challenges presented by AMR, in collaboration with RTI International, a nonprofit research institute with expertise in scoping reviews, expert elicitation, and multi-criteria decision analysis. NIAMRRE expertise includes investigators and subject matter experts from four major agricultural research universities with deep expertise in animal health and livestock production: University of California Davis (dairy cattle lead), The Ohio State University (beef cattle lead), the University of Georgia (broiler chicken lead), and Iowa State University (swine lead). Collectively, this team provides an outstanding environment for successful completion of the project. The outcome of this framework is that a consistent approach will be applied across four major livestock species, resulting in consistent communications of recommendations for strategies to reduce reliance on medically important antimicrobials.