Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools

总括 项目摘要/摘要 加州大学戴维斯分校非人灵长类测试中心体细胞鉴定 基因组编辑工具将支持对非人类灵长类动物的研究，这将推动基因组编辑领域的发展， 并为这些治疗人类疾病的技术的未来转化做出重大贡献。 非人灵长类测试中心汇聚了一支强大的多学科调查团队， 利用加州大学戴维斯分校的主要优势的校园合作伙伴关系，包括加州国家灵长类动物 研究中心、基因组中心、临床和翻译科学中心。非人灵长类 检测中心将为体细胞基因组编辑(SCGE)获奖者提供最先进的功能 在非人类灵长类动物中进行高质量的研究。非人灵长类测试中心利用 表现出长期致力于提供研究机会的支持性框架 以及与全国调查人员的合作。通过这种强大的基础设施，非人类灵长类 考试中心提出了以下具体目标：(1)提供行政和组织架构 促进非人灵长类的体细胞基因组编辑研究，(2)促进与SCGE的伙伴关系 获奖者通过提供加速他们的研究的资源，以及(3)确保整个 SCGE方案和联盟通过与传播和协调中心的透明互动， SCGE工作组和项目指导委员会，以及美国国立卫生研究院。我们强大的多学科团队是 加州大学戴维斯分校非人灵长类测试中心的深度和广度 支持全国SCGE研究人员的体细胞基因组编辑工具，并为 共同基金SCGE计划。

Overall PROJECT SUMMARY / ABSTRACT The University of California (UC) Davis Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools will support studies in nonhuman primates that will advance the genome editing field, and significantly contribute to the future translation of these technologies for the treatment of human disease. The Nonhuman Primate Testing Center brings together a robust team of multidisciplinary investigators with campus partnerships that capitalize on major strengths at UC Davis including the California National Primate Research Center, Genome Center, and Clinical and Translational Science Center. The Nonhuman Primate Testing Center will offer state-of-the-art capabilities for Somatic Cell Genome Editing (SCGE) awardees to conduct high quality research in nonhuman primates. The Nonhuman Primate Testing Center leverages a supportive framework that has demonstrated a long-standing commitment to providing research opportunities and collaborations to investigators nationwide. Through this powerful infrastructure the Nonhuman Primate Testing Center proposes the following Specific Aims: (1) Provide an administrative and organizational structure to advance somatic cell genome editing studies in nonhuman primates, (2) Foster partnerships with SCGE awardees through provision of resources that accelerate their research, and (3) Ensure synergism across the SCGE Program and Consortium via transparent interactions with the Dissemination and Coordinating Center, SCGE Working Group and Program Steering Committee, and the NIH. Our robust multidisciplinary team is poised to bring the depth and breadth of the UC Davis Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools to support SCGE investigators nationwide and contribute substantially to the Common Fund SCGE Program.