Renovation of Core Laboratories for the DC Intellectual and Developmental Disabilities Research Center

项目摘要 儿童国立医院（CNH）建议搬迁15，520 GSF的先进核心设施研究空间 以支持其NIH资助的哥伦比亚特区智力和发育障碍研究中心 (DC-IDDRC）。该项目的搬迁和扩建将从CNH Sheikh Zayed校区转移到 新的儿童国家研究和创新校园位于前沃尔特里德陆军医疗 中心位于华盛顿，华盛顿特区西北部，离医院4英里。该项目涉及 原武装部队病理学研究所大楼一层楼的翻修/现代化 建于1955年。这项建筑的总费用估计为9 446 951美元。CO 6要求 预算为8，000，000美元，其余费用（约1，446，951美元）由CNH提供。这 最先进的核心设施将允许进行和扩大遗传和神经科学研究 DC-IDDRC是一个跨学科和跨机构的研究中心。这个的使命 IDDRC旨在改善对发育障碍儿童的理解和治疗，包括 自闭症、脑瘫、癫痫、遗传性代谢紊乱和智力残疾。新的空间将 支持3个核心，可供组成DC-IDDRC的四个机构的调查人员访问： CNH、乔治华盛顿大学（GW）、乔治敦大学和霍华德大学。建设 还将包括DC-IDDRC研究人员的共享酒店实验室空间，其实验室不在- 但谁在使用核心设施。建议的DC-IDDRC核心包括：1）细胞和组织 显微镜，2）基因组学和生物信息学，以及3）诱导多能干细胞（IPSC）。

Project Summary Children’s National Hospital (CNH) proposes to relocate 15,520 GSF of advanced core facility research space in support of its NIH funded District of Columbia Intellectual and Developmental Disabilities Research Center (DC- IDDRC). The relocation and expansion of this program will be from CNH Sheikh Zayed campus to the new Children’s National Research and Innovation Campus located at the former Walter Reed Army Medical Center site in Northwest Washington, D.C., 4 miles from the hospital. The project involves renovation/modernization of one floor of the former Armed Forces Institute of Pathology building originally constructed in 1955. The total cost of this construction is estimated to be $9,446,951. This CO6 requests a budget of $8,000,000 with the remainder of the cost (approximately $1,446,951) being funded by CNH. This state-of-the-art core facility will allow the conduct and expansion of genetic and neuroscience research initiatives of the DC-IDDRC, an interdisciplinary and inter-institutional research center. The mission of this IDDRC is to improve the understanding and treatment of children with developmental disabilities, including autism, cerebral palsy, epilepsy, inherited metabolic disorders and intellectual disability. The new space will support 3 cores that will be accessible to investigators from the four institutions that comprise the DC-IDDRC: CNH, George Washington University (GW), Georgetown University and Howard University. The construction will also include shared hoteling laboratory space for DC-IDDRC investigators whose laboratories are not on- site but who are utilizing the core facility. The proposed DC-IDDRC cores consist of: 1) Cell and Tissue Microscopy, 2) Genomics and Bioinformatics, and 3) Induced Pluripotent Stem Cells (IPSC).