ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction

项目总结 此补充请求寻求将基于任务的功能磁共振数据添加到谜上瘾的数据POP努力中 组)。谜-成瘾对成瘾相关的神经成像进行二次巨型和元分析- 基因数据集。数据池解决了神经成像领域中存在的实质性问题 与小样本相关，导致研究动力非常薄弱。目前，《谜之瘾》包括152部 独特的研究，由17个国家57个不同机构的86名首席调查人员贡献，总计 大约20,000名参与者，此外，还使用公开可用的数据集(例如，ABCD，HCP， 英国生物库)。到目前为止，我们主要关注结构数据(高分辨率解剖和扩散加权 扫描)和休眠状态功能连通性数据。然而，这是扩展到基于任务的模式的理想时机 功能磁共振成像，具体地说，在物质-呈现期间的大脑激活(和功能连接)- 相关线索称为fMRI药物线索反应性(FDCR)。我们最近对FDCR研究进行了系统的回顾 确定了从1998年到2020年发表的357项研究(Ekhtiari 2022)。尽管存在异构性，但 在357项研究中，252项使用了图片提示，其中217项使用了阻塞的 设计。此外，我们在最近的协商一致研究(Ekhtiari)中解决了方法报告问题 等人的研究。2022年)，现在有一个专门的谜团工作组制定了完善的程序 用于多点基于任务的功能磁共振数据的协调分析。我们将收集最低限度的预处理数据 来自世界各地感兴趣的实验室，以及我们现有的谜上瘾程序。初步分析将 包括对联合注册和预处理的功能性粗体扫描的输出进行大量分析 参与者使用谜半管道，以获得和比较全脑药物&gt；中性对比图 参与者有和没有SUD，并以出价格式存储他们。

PROJECT SUMMARY This supplement request seeks to add task-based fMRI data to the data pooing efforts of the ENIGMA-Addiction group). ENIGMA-Addiction performs secondary mega- and meta-analyses of addiction-relevant neuroimaging- genetic datasets. The data pooling addresses the substantial concerns that exist within the neuroimaging field related to small samples leading to very poorly powered studies. Currently, ENIGMA-Addiction includes 152 unique studies, contributed by 86 Principal Investigators at 57 different institutions in 17 countries, totaling approximately 20,000 participants and, additionally, works with publicly available datasets (e.g., ABCD, HCP, UKBiobank). Thus far, we have focused on structural data (high resolution anatomical and diffusion weighted scans) and resting-state functional connectivity data. However, this is an ideal time to expand into task-based functional MRI, specifically, brain activation (and functional connectivity) during the presentation of substance- related cues called fMRI drug cue-reactivity (FDCR). Our recent systematic review of FDCR studies has identified 357 studies published from 1998 to 2020 (Ekhtiari 2022). Although there are heterogeneities in the details of the conducted studies, 252 of the 357 studies used pictorial cues and 217 of them used a blocked design. Moreover, we have tackled the methodological reporting issues in our recent consensus study (Ekhtiari et al. 2022) and there are now well-established procedures developed by a dedicated ENIGMA working group for the harmonized analyses of multi-site task-based fMRI data. We will collect minimally pre-processed data from the interested labs across the world with our existing ENIGMA-Addiction procedures. Primary analysis will consist of a mega-analysis of output from co-registered and pre-processed functional BOLD scans for individual participants using ENIGMA HALFPipe, to obtain and compare whole-brain drug>neutral contrast maps for participants with and without SUD and store them in BIDS format.