GROWING LOCAL: SUSTANING EPIGENOMICS RESEARCH AT UND

北达科他州大学 发育和疾病的表观遗传学 整体 项目摘要 这个COBRE II应用程序的目标是扩大和加强对表观遗传的研究 北达科他州大学的一项研究， 为表观遗传学工作组（EWG）提供持续支持。在COBRE I中，EWG 在发展表观遗传学/表观基因组学项目方面取得了重大进展 通过支持个别项目;招聘表观遗传学专家到我们的小组， 通过指导计划支持教师发展。我们建立了全面的 基因组学核心，以满足表观遗传学社区的需求，并提供技术和 财政支持，增加了我们社区利用表观遗传学的研究人员的数量， 接近。在第一阶段，我们的COBRE调查人员取得了重要发现， 在高影响力期刊上发表了253篇论文，66篇海报和口头报告 应邀参加研讨会或科学会议的领导人，并获得超过1080万美元的奖励 外部资金主要来自R 01，R21和NSF赠款。 在这里，我们寻求通过继续和扩大这些活动来保持这一势头。 通过以下策略计划：我们将招募具有兴趣和专业知识的教师， 扩大我们的团队规模，并将我们的能力扩展到机械和翻译领域。 我们将加强基因组核心的产品，以进一步提高我们的能力， 小组进行高质量的研究;我们将提高我们的研究人员的能力， 通过支持个别项目和科学和教师过渡到独立资助 发展辅导计划。我们的长期目标是将EWG转变为 可持续科学中心致力于了解分子机制 发展和病理障碍，将吸引顶尖人才，培养下一代的 科学家，并成为尖端表观遗传学研究的区域中心。 ! ! !

UNIVERSITY OF NORTH DAKOTA EPIGENOMICS OF DEVELOPMENT AND DISEASE OVERALL PROJECT SUMMARY The goal of this COBRE II application is to expand and enhance research into epigenetic mechanisms underlying development and disease at the University of North Dakota by providing ongoing support to the Epigenetics Working Group (EWG). In COBRE I the EWG made significant progress towards development of an epigenetics/epigenomics program through support of individual projects; recruitment of epigenetics experts to our group and supporting faculty development through mentoring programs. We established a comprehensive Genomics Core to meet the needs of the epigenetics community and provided technical and financial support that increased the number of researchers in our community utilizing epigenetic approaches. In Phase I our COBRE Investigators made important discoveries that resulted in 253 papers published in high impact journals, 66 poster and oral presentations by Project Leaders at invited seminars or scientific meetings, and the awarding of more than $10.8 million in external funding primarily from R01, R21, and NSF grants. Here we seek to maintain this momentum through continuation and expansion of these programs via the following strategies: We will recruit faculty with interests and expertise that increase the size of our group and extend our competencies into mechanistic and translational areas; We will enhance the offerings of the Genomics Core to further increase the ability of our group to perform high-quality research; We will enhance the ability of our investigators to transition to independent funding through support of individual projects and scientific and faculty development mentoring programs. Our long-term goal is to transition the EWG into a sustainable scientific center dedicated to understanding molecular mechanisms of developmental and pathological disorders that will attract top talent, train the next generation of scientists, and become a regional hub for cutting edge epigenetics research. ! ! !