Africa Hepatopancreatobiliary Cancer Consortium

摘要 肝胆癌和胰腺癌是一组迅速致死的恶性肿瘤，人们对此知之甚少。 病原学和生物学。这些癌症通常在晚期确诊，即在原发肿瘤扩散到 邻近或远处的器官，不能进行治疗。非洲人患这些癌症的几率比 美国人、亚洲人或欧洲人。非洲人也更有可能在年轻时被诊断出患有这些癌症。 与世界上许多其他种族/族裔群体相比，这些癌症的死亡率更高。 非洲肝胆和胰腺癌研究进展的重大限制是有限的 临床医生和科学家在新兴研究方面的持续培训，诊断能力有限，以及 分配给肝脏、胆管和胰腺癌研究的资源有限，尽管公众越来越多 这些癌症造成的健康负担。为了解决日益严重的高发病率和 在非洲，迫切需要(1)识别和授权 拥有该领域最新知识和研究技能的新兴癌症研究人员和临床医生 有助于理解与这些癌症相关的病因和预后因素， 以及(2)帮助制定可持续的实际行动，以便进行早期诊断，并减少发病率和 这些癌症在非洲的死亡率。迫切需要利用我们的集体专业知识和资源 美国与非洲研究人员合作，在非洲推进肝胰腺癌的科学研究。 这项建议将组织一系列关于肝胆和胰腺科学研究的研讨会。 由该领域的专家领导的癌症。工作坊将包括以下方面的知识讲座： 这些癌症的病理生物学，设计适当的针对肝胆管和胆管的研究实验 胰腺癌，手稿写作工作坊，设计联合研究项目 非洲和美国，对研究协调员的项目管理培训，以及新的 实验室技术/技术。 在为期三年的R13赠款结束时，我们将加强在非洲和 美国正在努力解决肝胆癌和胰腺癌死亡率居高不下的问题。穿过 在这个项目中，我们将在非洲发展一支充满活力和协作的调查小组，配备有技能 对促进肝胆、胰腺癌的科学发展具有重要意义。预期中的 交付成果还包括非洲人和美国人之间的联合出版物和联合赠款申请 研究人员将加强在此R13应用程序下实现的研究协作。这个 我们研究合作的结果将提高对病因、生物学和 美国非洲人和非洲裔人群中肝胆和胰腺癌的预后 各州。

ABSTRACT Hepatobiliary and pancreatic cancers are a group of rapidly fatal malignancies with poorly understood etiology and biology. These cancers are often diagnosed at a late stage, after the primary tumor has spread to adjacent or distant organs, precluding curative therapy. Africans have higher incidences of these cancers than Americans, Asians, or Europeans. Africans are also more likely to be diagnosed with these cancers at younger ages and have a higher mortality from these cancers than many other racial/ethnic groups worldwide. Significant limitations to the advancement of hepatobiliary and pancreatic cancer research in Africa are limited continuous training in emerging research among clinicians and scientists, limited diagnostic capabilities, and the modest resources allocated to the liver, biliary and pancreatic cancer research despite the growing public health burden attributable to these cancers. To address the increasing problem of higher incidence and mortality of hepatobiliary and pancreatic cancers in Africa, there is a pressing need to (1) identify and empower emerging cancer researchers and clinicians with the most current knowledge and research skills in the field to contribute meaningfully to understanding the etiology and prognostic factors associated with these cancers, and (2) help develop sustainable, practical actions for early diagnosis and to reduce the incidence and mortality of these cancers in Africa. There an urgent need to harness our collective expertise and resources in the United States with African investigators to advance the science of hepatopancreatobiliary cancers in Africa. This proposal will organize a series of workshops on scientific research in hepatobiliary and pancreatic cancers led by experts in the field. The workshops will comprise of knowledge delivering lectures on the pathobiology of these cancers, design appropriate research experiments specific to hepatobiliary and pancreatic cancers, manuscript writing workshops, designing joint research projects among investigators in African and the United States, project management training for research coordinators, and training in new laboratory techniques/technology. At the conclusion of the three-year R13 grant, we will have enhanced the expertise in Africa and the United States to address the perennially high mortality rates of hepatobiliary and pancreatic cancers. Through this project, we will develop a vibrant and collaborative group of investigators in Africa, equipped with the skills to meaningfully contribute to advancing the science of hepatobiliary and pancreatic cancers. The expected deliverable also includes joint publications and joint grant applications among African and American investigators to augment the research collaboration that will be achieved under this R13 application. The results of our research collaborations will improve the understanding of the etiological factors, biology, and outcomes of hepatobiliary and pancreatic cancers in African and African-descent populations in the United States.