Biology at birth: the role of infancy in providing the foundation for lifetime success

婴儿期对任何有机体来说都是危险的时期，随着个体的移动， 从母体保护的环境到外部世界。巨大的解剖学，行为学， 生理变化从出生开始，并通过发展继续， 成年人的生存和成功。我们组织了一个研讨会，从一个 综合的观点，强调这段时间在任何个人的生活可以塑造其 整个未来。尽管所有临床领域的儿科医生、儿科医生和儿科专家 分支学科的培训广泛而深入，基础科学家之间的融合较少 他们为临床研究和治疗与康复的进展提供了基础。我们 我们的目标是汇集各种生命科学的基础科学和临床研究人员 跨学科界限的对话、协作和互动的学科， 在这个特定的发展时刻，促进新颖和创新研究的方式。我们 提出三项与我们的具体目标相一致的活动：组织主要和补充活动， 在2023年SICB会议（SA 1）上举行关于婴儿期专题讨论会; 参与者和受训者（SA 2）;并出版一期《综合与比较生物学》 包括所有平台和海报演示者，综合介绍和概述， 研讨会的结论（SA 3）。主要研讨会包括三个一般性议题：（1）如何 产前环境塑造婴儿表型;（2）围产期生理和发育;（3） 婴儿经历对表型和表现的纵向影响。 本次研讨会已被比较与综合学会接受， 生物学2023会议，我们的11位发言人已经接受，包括承诺提交一份 2023年初进行同行评审的手稿（根据社会和期刊指南）。我们已经开始 为我们的补充研讨会和海报会议招募发言人（对任何人开放， 社会）。致力于本次研讨会的演讲者跨越了多种生理学 系统（包括神经系统、心血管系统、肌肉骨骼系统、消化系统、内分泌系统）和 多个模型种属（人、猪、羊、啮齿动物）。我们预计， 在代表三个主题的个人之间，将激发互动和交叉- 受精这反过来将促进新的和综合性的工作， 生理学和婴儿期特有的病理生理学。

Infancy is a perilous time for any organism, with significant changes as individuals move from the maternal protected environment to the outside world. Massive anatomical, behavioral, and physiologic changes start at birth, and continue through development, with implications for adult survival and success. We have organized a symposium that addresses infancy from an integrated perspective, highlighting that this period of time in any individual’s life can shape its entire future. While neonatologists, pediatricians, and pediatric specialists across all clinical subdisciplines are broadly and deeply trained, less integration exists amongst the basic scientists who provide the substrate for clinical research and advances in treatment and rehabilitation. Our goal is to bring together basic science and clinical researchers across various life science disciplines for conversation, collaboration, and interaction across disciplinary boundaries as a way of promoting novel and innovative research at this specific moment of development. We propose three activities, which align with our Specific Aims: organize Main and Supplemental symposia on infancy at 2023 SICB meeting (SA1); a organize lunchtime workshop for participants and trainees (SA2); and publish an issue of Integrative & Comparative Biology including all platform and poster presenters, a synthetic introduction, and an overview and conclusions of the workshop (SA3). The main symposium includes three general topics: (1) how the prenatal environment shapes infant phenotype; (2) perinatal physiology and development; (3) the longitudinal impacts of infant experiences on phenotype and performance. This symposium as already been accepted for the Society of Comparative and Integrative Biology 2023 meeting, and our 11 speakers have accepted, including a commitment to submit a manuscript for peer review in early 2023 (per society and journal guidelines). We have begun recruiting speakers for our Supplemental Symposium and poster sessions (open to anyone within the society). The speakers who have committed to this symposium span multiple physiologic systems (including neurological, cardiovascular, musculoskeletal, digestive, endocrine) and multiple model species (humans, pigs, sheep, rodents). We anticipate that the discussions among individuals representing the three topic headings will galvanize interactions and cross- fertilizations. This in turn will promote new and integrative work on the both the underlying normal physiology and the specific pathophysiologies that characterize infancy.