A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican children

项目摘要 该K 08申请旨在检查抑制性控制困难的潜在胎儿来源：子宫内暴露 产前母亲肥胖症。这项研究填补了一个关键的空白，通过检查抑制控制缺陷，在一个 波多黎各人在美国的代际样本。这个社区，与其他拉丁裔人口一样， 肥胖症和与冲动有关的疾病，如注意力缺陷/多动症， （ADHD），但仍大大不足研究。这个为期五年的K 08申请提出了一个研究计划， 支持申请人成为独立调查员的培训，重点是 通过跨学科方法研究抑制性控制缺陷的早期起源（生命历程 流行病学、婴儿神经成像和生物统计学）。培训计划建立在候选人之前的培训基础上 和经验，并利用优秀的导师团队和研究环境，以促进 发展候选人在以下方面的专业知识：（1）收集、分析和解释婴儿静息状态 功能磁共振成像（fMRI）数据;（2）围产期体重与炎症及其关系 胎儿神经发育;（3）少数民族/种族人群的生命过程流行病学研究;（4） 现象学和幼儿抑制控制的评估;（5）科学中的负责任行为 research.本研究将探讨高孕妇产前体重指数（BMI）对新生儿的影响。 额纹连接（即，涉及抑制性控制障碍的神经回路）（目标1）， 对2岁时抑制控制的行为评估（目标#2）。据推测，炎症是一个关键 母亲产前BMI导致额纹状体连接中断的介质（即机制）， 婴儿和幼儿的抑制控制受损。该项目将收集孕妇的产前评估， BMI和炎症，2-4周龄婴儿的静息状态fMRI数据，以及行为和父母 报告2岁时抑制控制能力的测量结果。目前，拟定的研究参与者已入组 在NIH环境对儿童健康结果的影响（ECHO）研究中，该研究将收集以下方面的MRI数据： 500个婴儿在此结构的基础上，我们建议选择一个平均（BMI=18.5- 18.5）的子样本（n=76）。 24.9 kg m−2; n=38）和肥胖（BMI？30 kg m−2; n=38）孕妇及其后代纳入本项目。 从拟议的研究中获得的数据将导致未来的R 01应用程序检查后代的抑制作用。 纵向控制电路。研究和培训经验和专门知识共同发展， 通过这个K 08奖将支持申请人的过渡到研究的独立性，并确保 申请人成为抑制性控制缺陷的产前起源的主要权威。

PROJECT SUMMARY This K08 application aims at examining a potential fetal origin of inhibitory control difficulties: in utero exposure to prenatal maternal obesity. This study fills a crucial gap by examining inhibitory control deficits in an intergenerational sample of Puerto Ricans in the US. This community, alongside other Latino populations, has seen an increase in obesity and impulsivity-related disorders such as attention-deficit/hyperactivity disorder (ADHD), yet remains vastly understudied. This five-year K08 application presents a program for research and training that will support the applicant on a path towards becoming an independent investigator, focused on studying the early origins of inhibitory control deficits through an interdisciplinary approach (life course epidemiology, infant neuroimaging, and biostatistics). The training plan builds on the candidate's prior training and experience and capitalizes on an outstanding mentorship team and research environment to foster the development of the candidate's expertise in (1) collection, analysis, and interpretation of infant resting state functional Magnetic Resonance Imaging (fMRI) data; (2) perinatal weight and inflammation and its relationship to fetal neurodevelopment; (3) life course epidemiologic research with ethnic/racial minority populations; (4) phenomenology and assessment of inhibitory control in toddlers; and (5) responsible conduct in scientific research. This project will investigate the influence of high maternal prenatal body mass index (BMI) on frontostrialal connectivity (i.e., circuits implicated in inhibitory control disorders) in offspring infants (Aim #1) and on behavioral assessments of inhibitory control at age 2 (Aim # 2). It is hypothesized that inflammation is a key mediator (i.e. mechanism) by which maternal prenatal BMI leads to disruptions in frontostriatal connectivity in infants and impaired inhibitory control in toddlers. The project will collect prenatal assessments of maternal BMI and inflammation, resting state fMRI data from infants at 2-4 weeks of age, and behavioral and parent report measures of inhibitory control abilities at age 2. Currently, the proposed study participants are enrolled in the NIH Environmental influences on Child Health Outcomes (ECHO) study, which will collect MRI data on 500 infants. Building on this structure, we propose to select a subsample (n=76) of average (BMI=18.5– 24.9 kg m−2; n=38) and obese (BMI?30 kg m−2; n=38) pregnant women and offspring to include in this project. Data yielded from the proposed study will lead to a future R01 application examining offspring's inhibitory control circuits longitudinally. Together, the research and training experiences and expertise developed through this K08 award will support the applicant's transition to research independence and ensure the applicant becomes a leading authority in the prenatal origins of inhibitory control deficits.