Affective Sensory Pathways of Light Stroking and Deep Pressure Touch

行政补充提案：摘要 R 00 AT 009466：轻抚摸和深压触摸的情感感觉通路 博士凯斯是加州大学麻醉学系的助理教授 圣地亚哥（加州大学圣地亚哥分校）.在克服了与covid相关的延迟后，她对r 00的机制的研究 情感触摸运行平稳，并与她目前的SARP的轨道。拟议行政 补充要求增加两个高度创新的目的，以增加原来的影响， 拟定的建立基于感觉的补充剂的新作用机制的研究 比如按摩疗法。现有的R 00研究旨在确定钝化的潜在因素， 慢性疼痛患者的情感触觉感知，并比较疼痛缓解机制 以及轻度轻柔的抚摸和深压对纤维肌痛（FM）患者和健康人的影响 对照目前的行政建议增加了两个目标：5）确定当地的影响， 6）确定皮下OT对实验性疼痛的局部作用， 触摸愉悦。最近在啮齿动物中的研究表明，催产素强烈调节C纤维 在脊髓和末端轴突。在人类中，系统性催产素调节情感触摸 皮肤注射可减少术后疼痛。然而，催产素的外周效应， 情感触觉从未在人类身上测试过。研究结果预计将显着 影响对触摸愉悦的外周通路机制的基本理解， 减轻疼痛。我们希望该项目能够导致竞争性R 01提交，以测试局部效应是否 慢性疼痛患者的催产素水平不同，这些患者表现出C-伤害感受器敏感性和触觉减少 愉快这一贡献将告知后续的研究机制的手触摸疗法 并为测试慢性疼痛个体的差异提供了新的方向。

Administrative Supplement Proposal: Abstract R00 AT009466: Affective Sensory Pathways of Light Stroking and Deep Pressure Touch Dr. Case is as an Assistant Professor in the Department of Anesthesiology at the University of California San Diego (UC San Diego). After overcoming covid-related delays, her R00 study on mechanisms of affective touch is running smoothly and on track with her current SARP. The proposed administrative supplement is requested to add two highly innovative aims to increase the impact of the originally proposed study in establishing novel mechanisms of action for sensory-based complementary approaches such as massage therapy. The existing R00 study seeks to identify factors underlying blunted affective touch perception in individuals with chronic pain, and to compare the pain-relieving mechanisms and effects of light gentle stroking and deep pressure between patients with Fibromyalgia (FM) and healthy controls. The current administrative proposal adds two aims: 5) Determine the local effect of subcutaneous OT on experimental pain and 6) Determine the local effect of subcutaneous OT on touch pleasantness. Recent research in rodents demonstrates that oxytocin strongly modulates C-fibers in the spinal cord and at the terminal axon. In humans, systemic oxytocin modulates affective touch perception, and skin injection reduces postsurgical pain. However, peripheral effects of oxytocin on affective touch perception have never been tested in humans. Study results are expected to significantly impact fundamental understanding of the mechanisms of peripheral pathways for touch pleasantness and pain reduction. We expect this project to lead to a competitive R01 submission to test whether local effects of oxytocin differ in patients with chronic pain, who exhibit C-nociceptor sensitization and reduced touch pleasantness. This contribution will inform subsequent research on mechanisms of manual touch therapies and provide a new direction to test differences in individuals with chronic pain.