Administrative Core for Institution # 269291

总结 中央行政和管理核心的主要目标是充当锚， 为天普大学综合神经艾滋病毒中心（CNHC）提供行政监督， 费城的德雷克塞尔大学。总体目标是改善和扩大与神经艾滋病毒有关的研究 和与CNS病毒感染相关的神经系统疾病，包括神经行为损伤， 精神障碍CNHC在过去10年中创建的基础设施提供了独特的专业知识， 地方，地区和国家的神经HIV研究人员，重点是我们的基因编辑和交付的优势， 哺乳动物祖细胞和iPSC培养物，协助研究人员对病毒感染的细胞进行遗传分析 前后编辑程序，并支持全方位的最先进的显微镜和成像 分析.同时，CNHC将协调NeuroHIV社区伙伴关系和差异核心 影响PWH，新开发的核心，现在包括在我们的计划。CAMC将协助联络 与当前和潜在的社区合作伙伴，促进患者群体和 参与研究者。Tkhe中心在功能性细胞分析方面拥有独特的专业知识，包括 微电极阵列测定以研究神经元细胞响应于外部应力的行为。而且 中心将使研究者能够对一个成熟的队列进行临床和神经行为检查 在德雷克塞尔大学医学院纵向检查的艾滋病毒感染者（PWH）。CAMC将 为协调和监督CNHC的所有活动提供基础设施， 核心和其他NIMH支持的中心之间的互动。CAMC将制定战略计划， 确定短期和长期目标，执行详细的实施计划，开展内部和外部 以既定标准为基础的审查和评估工具，以确保资源的有效利用 实现CNHC的总体目标。它还将为数据分析提供生物统计支持， 从基础科学和临床核心中获得的解释。此外，该核心将与 科学核心向参与者和核心用户传播信息，招募核心用户， 试点应用程序，对核心产生的所有原始数据进行编目，促进和跟踪分发的所有材料 包括但不限于细胞系、病毒库和临床标本。

SUMMARY The main objective of the Central Administrative and Management Core (CAMC) is to serve as the anchor and to provide administrative oversight for the Comprehensive NeuroHIV Center (CNHC) at Temple University and Drexel University in Philadelphia. The overall objective is to improve and expand research related to neuroHIV and neurological diseases associated with viral infection of the CNS including neurobehavioral impairment and mental disorders. The infrastructure created by the CNHC during the last 10 years offers unique expertise to local, regional, and national neuroHIV investigators with focus on our strengths of gene editing and delivery, mammalian progenitor cells and iPSC cultures, assist investigators with genetic analysis of virus-infected cells before and after editing procedures, and support for a full-range of state-of-the-art microscopic and imaging analysis. At the same time, the CNHC will coordinate the NeuroHIV Community Partnership and Disparity Core affecting PWH, the newly developed core that is now included in our program. The CAMC will assist with liaising with current and potential community partners in fostering synergy among the patient population and the participant researchers. Tkhe Center offers its unique expertise in functional cellular assays including microelectrode array assay to study neuronal cell behavior in response to external stress. Furthermore, the Center will enable investigators to initiate clinical and neurobehavioral examination with a well-established cohort of people with HIV (PWH) longitudinally examined at Drexel University College of Medicine. The CAMC will provide the infrastructure for coordinating and overseeing all activities of the CNHC and facilitating synergistic interaction among the cores and other NIMH-supported Centers. The CAMC will delineate the strategic plan, identify short- and long-term objectives, execute detailed plans to be implemented, carry out internal and external reviews and assessment tools based on established criteria to ensure productive and efficient use of resources to achieve the overall objectives of the CNHC. It will also offer biostatistical support for data analysis and interpretation obtained from the basic science and clinical cores. In addition, this Core will coordinate with the Scientific Cores to disseminate information to the participants as well as Core users, recruit Core users, solicitate pilot applications, catalogue all original data generated by the Cores, facilitate and track all material distributed by the Cores, including, but not limited to, cell lines, viral stocks, and clinical specimens.