New York Obesity Research Center

项目总结/摘要 纽约肥胖营养研究中心（NYNORC）的主要目标是召集和支持- 由哥伦比亚大学的核心服务、试点和可行性以及丰富项目资助的研究人员 和阿尔伯特·爱因斯坦医学院研究肥胖症。该中心的主题包括：病因学， 肥胖症的病理生理学和并发症;治疗策略;体重调节的生理学， 营养素的使用;开发新的工具和战略，研究营养和肥胖;和培训， 发展科学家研究营养和肥胖。NYNORC的一个特殊优势是，通过设计， 明确承诺促进多学科研究，其中纳入与以下方面有关的基本观察： 营养，代谢和行为生物学，与应用这些见解的临床方法， 预防和治疗肥胖症。我们基地的规模和广度为以下方面提供了坚实的基础： 协作和生产力。在本周期内，研究基地已从109个增加到115个。 成员目前，NYNORC成员是206个肥胖相关赠款的PI，总额为6000万美元/年。 直接费用：来自NIH的166笔赠款，总计4800万美元/年（1300万美元NIDDK）和40个基金会， 制药实体支持肥胖相关的赠款总额为1100万美元/年。NYNORC成员包括 12个NIH培训赠款的PI，14个P30和P50计划项目，哥伦比亚的CTSA，以及10 K的导师 4个F31毕业生奖项。这些努力得到了我们三个生物医学研究核心的支持： 人类表型、动物表型和分子生物学/分子遗传学。自上次提交以来， 核心已为115名成员提供了约40，000项服务，其中包括人类提供的约8464项服务。 表型分析核心，来自动物表型分析核心的10，231项服务， 分子遗传学/分子生物学核心该研究基地还得到了一个非常成功的试点项目的支持。 和可行性计划-由赞助机构补贴-向13个国家提供120万美元 自上一次提交以来，已有3名调查人员获得了奖励，今年夏天开始将有3名新的奖励。另外通过 Naomi Berrie糖尿病中心在糖尿病研究前沿的项目， 肥胖的神经生物学和最近启动的初步转化研究计划， NYNORC每年可获得约200万美元的额外资金，用于支持与以下方面相关的创新研究： 肥胖症的发病机制和治疗。NYNORC是一家充满活力的企业，拥有强大的机构 支持允许它发展和繁荣，因为它在肥胖研究中促进了新的和协作的科学。这 NYNORC的成员在创造智力和物质资源方面的作用是显而易见的， 解决COVID-19流行病的基础和转化研究方法。

PROJECT SUMMARY/ABSTRACT The New York Obesity Nutrition Research Center (NYNORC) has as its primary aim to convene and support - by its Core Services, Pilot & Feasibility and Enrichment programs - funded investigators at Columbia University and the Albert Einstein College of Medicine studying obesity. The themes for this Center include: the etiology, pathophysiology and complications of obesity; treatment strategies; the physiology of weight regulation and nutrient use; development of new tools and strategies for the study of nutrition and obesity; and the training and development of scientists to study nutrition and obesity. A particular strength of the NYNORC, by design, is an explicit commitment to the promotion of multidisciplinary research that integrates basic observations relating to nutritional, metabolic and behavioral biology, with the application of these insights to clinical approaches to the prevention and treatment of obesity. The size and breadth of our base has provided a strong basis for collaborations and productivity. During the current cycle, the research base has grown from 109 to 115 funded members. Currently, NYNORC members were PIs on 206 obesity-related grants totaling $60M/annum in direct costs: 166 grants from NIH totaling $48M/annum ($13M NIDDK) and 40 foundations and pharmaceutical entities supported obesity-related grants totaling $11M/annum. NYNORC Members are PIs of 12 NIH training grants, 14 P30 and P50 program projects, the CTSA at Columbia, and mentors of 10 K series and 4 F31 graduate awards. These efforts are supported by our three Biomedical Research Cores: Human Phenotyping, Animal Phenotyping and Molecular Biology/Molecular Genetics. Since the last submission, the Cores have provided ~40,000 services to 115 members, including ~8464 services provided by the Human Phenotyping Core, 10,231 services from the Animal Phenotyping Core and >20,000 service requests by the Molecular Genetics/Molecular Biology Core. The research base is also supported by a highly successful Pilot & Feasibility Program – subsidized by the sponsoring institutions - that awarded $1.2M to 13 investigators since the last submission and 3 new awards to begin this summer. In addition, through the Naomi Berrie Diabetes Center programs in Frontiers in Diabetes Research, the Russell Berrie Initiative in the Neurobiology of Obesity and the recently inaugurated Preliminary Translational Research Program, the NYNORC has access to an additional ~$2M in annual funds to support innovative studies related to the pathogenesis and treatment of obesity. The NYNORC is a dynamic enterprise that has strong institutional support permitting it to evolve and thrive as it fosters novel and collaborative science in the study of obesity. This evolution is apparent in the role of members of the NYNORC in creating intellectual and physical resources for addressing basic and translational research approaches to COVID-19 epidemic.