In Vivo Translational Imaging Shared Resource

体内翻译成像共享资源（IVTISR） 项目总结/摘要 体内翻译成像共享资源（IVTISR）的开发旨在为加州大学戴维斯分校 综合癌症中心（UCDCCC）成员在快速发展的非癌症领域的杰出资源， 侵入性成像技术，解决UCDCCC成员对这些技术的强烈需求。 在人类疾病的动物模型和人类中的体内成像是解决癌症的一个组成部分 结果以及评估和解决诊断和治疗方法。IVTISR规定， 体内成像设备，以及专用成像协议和专业知识，这对推进 了解癌症的基本机制，以及新的肿瘤诊断和 临床治疗工具。还提供了关于涉及体内成像的实验设计的指导， 机构动物护理和使用委员会（IACUC）和机构审查委员会（IRB）方案，成像 数据分析和解释，以及手稿和赠款编制/预算。IVTISR 由三个单位组成;分子和基因组成像中心（CMGI），支持小动物在 体内成像，生物标本成像和临床前放射化学，成像科学中心（CIS）， 支持大型动物的成像研究，以及EXPLORER分子成像中心（EMIC）， 支持人体正电子发射断层扫描/计算机断层扫描（PET/CT）研究。所以作为 整个这一共享资源独特地支持从啮齿动物癌症模型到大型动物的成像研究 例如患有自发性癌症的猫和狗，到患有肿瘤病症的人。监督和 IVTISR的管理由CMGI主任Abhijit Chaudhari，MS，PhD提供 在动物和人类癌症成像方面有超过15年的各种成像模式的经验， 定量成像科学、成像生物标志物设计和验证以及医学图像处理; 主任，Allison Zwingenberger，DVM，MAS，董事会认证的兽医放射科医生， 在癌症伴侣动物模型中使用CT、MRI和超声进行癌症成像的经验;以及 共同主任，Lorenzo Nardo，医学博士，放射科医生，在MRI、CT和分子成像方面接受过广泛培训 癌症的诊断、随访和治疗。IVTISR的具体目标是：1）提供 UCDCCC成员可以获得广泛的体内成像技术，包括分子成像 技术，例如PET、单光子发射计算机断层扫描（SPECT）和光学成像， 超声定量生理成像，CT和磁共振解剖成像 成像（MRI）。2)提供规划、执行和分析体内成像研究的专业知识。3)支持 啮齿动物模型（主要在CMGI）中的成像研究，在自发性癌症的大型动物中 （主要在CIS）和人类（主要在EMIC）。4)继续寻求最先进的体内成像 这些技术将增强UCDCCC成员的研究努力。

IN VIVO TRANSLATIONAL IMAGING SHARED RESOURCE (IVTISR) PROJECT SUMMARY/ABSTRACT The In Vivo Translational Imaging Shared Resource (IVTISR) was developed to provide UC Davis Comprehensive Cancer Center (UCDCCC) members outstanding resources in the rapidly evolving field of non- invasive imaging technologies, addressing the strong demand for these technologies by UCDCCC members. In vivo imaging in animal models of human disease and in humans is an integral part of addressing cancer outcomes and in assessing and addressing diagnostic and therapeutic approaches. The IVTISR provides in vivo imaging equipment, and dedicated imaging protocols and expertise that are critical to the advancement of understanding basic mechanisms of cancer as well as the translation of new oncologic diagnostic and therapeutic tools to the clinic. Guidance is also provided on experimental design involving in vivo imaging, Institutional Animal Care and Use Committee (IACUC) and Institutional Review Board (IRB) protocols, imaging data analysis and interpretation, as well as on manuscript and grant preparation/budgeting. The IVTISR consists of three units; the Center for Molecular and Genomic Imaging (CMGI) that supports small animal in vivo imaging, biospecimen imaging and preclinical radiochemistry, the Center for Imaging Science (CIS) that supports imaging studies in large animals, and the EXPLORER Molecular Imaging Center (EMIC), that supports human positron emission tomography/computed tomography (PET/CT) studies. Therefore, as a whole this shared resource uniquely supports imaging studies from rodent models of cancer to larger animals such as cats and dogs with spontaneous cancers to humans with oncologic conditions. Oversight and management of the IVTISR is provided by the Director, Abhijit Chaudhari, MS, PhD, the Director of the CMGI with over 15 years of experience in animal and human cancer imaging with various imaging modalities, quantitative imaging science, imaging biomarker design and validation and medical image processing; the co- Director, Allison Zwingenberger, DVM, MAS, a board-certified veterinary radiologist with extensive experience in cancer imaging using CT, MRI, and ultrasound in companion animal models of cancer; and the co-Director, Lorenzo Nardo, MD, PhD, radiologist with extensive training in MRI, CT, and molecular imaging in the diagnosis, follow up and treatment of cancer. The Specific Aims for the IVTISR are to: 1) Provide UCDCCC members with access to a broad range of in vivo imaging technologies, including molecular imaging technologies, such as PET, single photon emission computed tomography (SPECT) and optical imaging, quantitative physiologic imaging with ultrasound, and anatomic imaging with CT and magnetic resonance imaging (MRI). 2) Provide expertise in planning, executing and analyzing in vivo imaging studies. 3) Support imaging studies in rodent models (primarily at the CMGI), in larger animals with spontaneously arising cancers (primarily at the CIS), and humans (primarily at the EMIC). 4) Continue to seek state-of-the-art in vivo imaging technologies that will enhance UCDCCC members' research endeavors.