Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.

项目摘要 射血分数保留性心力衰竭（HFpEF）是最常见的心力衰竭形式，与 发病率和死亡率高，患病率增加，预后恶化。HFpEF患者的生活质量 与射血分数降低的心力衰竭一样差或更差，这在很大程度上是因为剧烈运动 不容忍;这种萌芽状态的主要表现。根据融资公告PAR-20-078 它支持使用现有的人类数据集进行重点突出的二次分析，以研究新的 对NHLBI相关生物医学或生物行为研究有潜在重大影响的方法， 我们将利用现有的心脏磁共振图像数据库， HFpEF患者和年龄和性别匹配的健康对照，以全面识别和表征 驱动HFpEF的病理生理机制。我们将使用一种新颖的单图像多端点分析 （SIMPL）方法比较四腔心功能（右心房、右心室、左心房、左心室） HFpEF和健康对照组之间的心室）、主动脉扩张性和心包脂肪负荷，并确定 它们与运动耐量和生活质量的独立和联合关联。

Project Summary Heart Failure with Preserved Ejection Fraction (HFpEF) is the most common form of heart failure, is associated with high morbidity and mortality, with increasing prevalence and worsening prognosis. Quality-of-life in HFpEF is as poor or worse than heart failure with reduced ejection fraction, in large part because of severe exercise intolerance; the primary manifestation of this bourgeoning condition. Per funding announcement PAR-20-078 which supports the use of existing human datasets for well-focused secondary analyses to investigate new methods that have the potential for significant impact on NHLBI relevant biomedical or biobehavioral research, we will leverage an existing database of cardiac magnetic resonance images in a cohort of well-phenotyped patients with HFpEF and age- and sex-matched healthy controls to comprehensively identify and characterize pathophysiologic mechanisms driving HFpEF. We will use a novel Single Image Multi-endPoint anaLysis (SIMPL) approach to compare four chamber cardiac function (right atrium, right ventricle, left atrium, left ventricle), aortic distensibility, and pericardial fat burden between HFpEF and healthy controls, and to determine their independent and combined association with exercise tolerance and quality of life.