ITEST: Innovative Tools to Expand Youth-Friendly HIV Self-Testing

摘要 拟议的补充是在我们的母ITEST研究的具体目标1和2的范围内 （UH3HD096929）。该补编侧重于相同的参与者群体（尼日利亚的AYA）， 使用相同的概念框架（青年参与行动研究），使用相同的 方法（众包公开呼吁），采用同样的重点实施科学， 同样，这也将有助于降低高危AYA中的艾滋病毒感染率。我们从最初的调查结果 AYA在尼日利亚的众包活动表明，AYA对PrEP的了解有限。 在2020年，几乎没有PrEP示范项目或国家指导建议 因此，我们的随机对照试验没有将PrEP摄取作为 次要结果，并没有关注PrEP。然而，最近有四个主要的 这些转变提供了一个独特的机会，现在可以专注于PrEP并告知尼日利亚国家PrEP （1）现在有更多的示范项目集中在PrEP之间， 风险个人，包括青少年（REFS）;（2）尼日利亚全国艾滋病毒预防 指导方针明确建议使用PrEP;4（3）青年领导的社区参与 我们UH 3项目所进行的项目表明，AYA有兴趣并愿意开始 PrEP（REFS）;（4）艾滋病毒自我检测与青年友好型诊所的联系率很高， 从我们的UH 3研究STD测试表明，这可能是一个可行的机制， 为尼日利亚高危AYA提供艾滋病毒预防服务。拟议的补编逻辑上是建立在 2021年众包公开征集和2022年设计竞赛的基金会， 重点是如何提高尼日利亚AYA的PrEP吸收。我们将利用强者 资源，基础设施和关系，已经在这个初始阶段发展 study.拟议的补充将由尼日利亚医学研究所领导， 由圣路易斯大学和北卡罗来纳州查佩尔山大学支持， 领导母公司UH 3研究的主要合作伙伴。我们的技能、经验和知识使我们 唯一有资格组织这项研究的团队。

Abstract The proposed supplement is within scope of Specific Aims 1 and 2 in our parent ITEST study (UH3HD096929). The supplement focus on the same participant population (AYA in Nigeria), use the same conceptual framework (youth participatory action research), uses the same methodologies (crowdsourcing open calls), adopts the same focus on implementation science, and similarly will help to decrease HIV incidence among at-risk AYA. Our findings from initial AYA crowdsourcing activities in Nigeria suggested that AYA had limited understanding of PrEP. In 2020, there were few PrEP demonstration projects or national guidance that recommended the use of PrEP. As a result, our randomized controlled trial did not have PrEP uptake as a secondary outcome and did not focus on PrEP. However, there have been four major recent shifts that provide a unique opportunity to now focus on PrEP and inform Nigerian national PrEP use among AYA: (1) There are now more demonstration projects focused on PrEP among at- risk individuals, including adolescents (REFS); (2) the national Nigerian HIV prevention guidelines explicitly recommend the use of PrEP;4 (3) youth-led community engagement programs conducted by our UH3 project demonstrate that AYA are interested and willing to start PrEP (REFS); (4) excellent rates of linkage from HIV self-testing into youth-friendly clinics and STD testing from our UH3 study suggest that this could be a feasible mechanism to organize HIV prevention services for at-risk Nigerian AYA. The proposed supplement logically builds on the foundation from the 2021 crowdsourcing open call and 2022 designathon which both focused on ways to enhance PrEP uptake among AYA in Nigeria. We will draw on the strong resources, infrastructure, and relationships that have been developed in the initial phases of this study. The proposed supplement will be led by the Nigerian Institute of Medical Research and supported by St. Louis University and the University of North Carolina at Chapel Hill, the three key partners which led the parent UH3 study. Our skills, experience, and knowledge make our team uniquely qualified to organize this research.