Research Training in Endocrinology and Metabolism

项目总结 这项拟议的博士后培训计划(2名研究员/年，2年制计划)在内分泌学和 新陈代谢将为认真致力于 从事生物医学研究和内分泌紊乱的研究。代谢性疾病代表着 美国的重大健康负担；这些疾病的病理生理学方面的进展需要 改善诊断、治疗和健康结果。威尔·康奈尔医学公司(Weill Cornell Medicine)正在经历 加速临床和生物医学研究活动的增长，这是由于对 在过去十年里，在劳里·格里姆彻博士和道格拉斯·格里姆彻博士担任院长期间，医学研究不断发展。 奥古斯丁·崔。对内科和内分泌科、糖尿病科的投资 新陈代谢一直很重要。安东尼·霍伦伯格博士，杰出的内分泌学家和甲状腺 生物学家，2018年被聘为医学系主任；他的支持推动了新陈代谢 在校园内优先进行研究，导致招聘和重大的内部和外部 资源。劳拉·阿隆索博士，这项提议的小岛生物学家和PD，于2019年被招聘为首席 内分泌科和威尔代谢健康中心主任，一个新组建的 校园新陈代谢研究小组有45名教职员工和150多名成员。我们的建议 T32领导团队还包括著名内分泌学家Julianne Imperato-McGinley博士 威尔康奈尔CTSC分部主任兼现任主任。然而，这项提议的推动力是 不是领导团队，而是那些一直在寻找学术道路的令人难以置信的实习生 即使在没有T32支持的情况下，医学也是如此。在过去的10年里，三位临床内分泌研究员成功地 获得K08奖项，目前领导着成功的学术研究事业，尽管缺乏 一名可用的T32；我们目前的一名二年级研究员被选为继续进行第三年的研究培训，甚至 尽管我们的项目被宣传为两年临床项目，而且两个即将到来的临床项目 2022年的研究员是杰出的研究人员，一个拥有加州理工大学的博士学位，另一个拥有第一个 作者自然医学在胰岛生物学上的论文，由我们的一位教员(罗博士)指导。我们 精心挑选了一支顶尖的研究团队，并设计了一套全面的教学培训 通过全面性指导计划，指导学员完成最终的R01提交。我们的招聘 计划是周密的，并非常重视招收顶尖的URM候选人。我们提议一个三位一体的 院校(WCM、MSKCC和RU)，严格的多学科T32，招收2名博士后医学博士或博士 学员每年参加为期2年的培训。该培训项目的负责人将与 以最大的热情和精力确保我们的学员发挥他们的潜力，出类拔萃并做出贡献 对学术内分泌界在未来几年具有重大意义。

PROJECT SUMMARY This proposed postdoctoral training program (2 fellows/year, 2-year program) in endocrinology and metabolism will provide comprehensive research training for individuals with a serious commitment to a career at the interface of biomedical research and endocrine disorders. Metabolic diseases represent significant health burden in the US; advances in the pathophysiology of these diseases are required to improve diagnostics, therapeutics and health outcomes. Weill Cornell Medicine (WCM) is experiencing accelerating growth in clinical and biomedical research activities, due to the singular emphasis on developing medical research over the past decade during the Deanships of Dr. Laurie Glimcher and Dr. Augustine Choi. Investment in the Department of Medicine and the Division of Endocrinology, Diabetes and Metabolism has been significant. Dr. Anthony Hollenberg, a prominent endocrinologist and thyroid biologist, was recruited to Chair the Department of Medicine in 2018; his support has catapulted metabolic research to a high priority on campus, resulting in recruitments and significant internal and external resources. Dr. Laura Alonso, islet biologist and PD on this proposal, was recruited in 2019 to be Chief of the Endocrinology Division and Director of the Weill Center for Metabolic Health, a newly assembled research group on campus focused on metabolism, with 45+ faculty and 150+ members. Our proposed T32 leadership team also includes Dr. Julianne Imperato-McGinley, renowned endocrinologist, prior Division Chief and current Director of the Weill Cornell CTSC. However, the impetus for this proposal is not the leadership team, but rather the incredible trainees that have been finding a path to academic medicine even without T32 support. Three clinical endocrine fellows in the past 10 years managed to obtain K08 awards and are currently leading successful academic research careers, despite the lack of an available T32; one of our current 2nd year fellows elected to pursue a 3rd year of research training even though our program has been advertised as a 2-year clinical program, and both of the incoming clinical fellows for 2022 are outstanding researchers, one with a PhD from Cal Tech and the other with a first author Nature Medicine paper in islet biology, mentored by one of our faculty preceptors (Dr. Lo). We have hand-picked a top team of research Preceptors, and designed a comprehensive didactic training plan with wrap-around mentoring to guide trainees through eventual R01 submission. Our recruitment plan is thorough and has a strong emphasis towards enrolling top URM candidates. We propose a tri- institutional (WCM, MSKCC and RU), rigorous multidisciplinary T32 to enroll 2 postdoctoral MD or PhD trainees annually for 2 years training duration each. The leaders of this training program will work with the utmost enthusiasm and energy to ensure that our trainees reach their potential to excel and contribute significantly to the academic endocrine community for years to come.