Specific Pathogen Free 18 Baboon Research Resource {(SPF18BRR): Resource Core

项目摘要：资源组成部分 SPF18BRR是国家唯一的不定病毒脱毒橄榄狒狒(Papio Anubis)研究资源 可供NIH受赠者使用；联邦机构的内部研究计划，包括FDA、NSF 和NIH；以及其他生物医学研究赞助商(私人基金会、制药公司和 合同研究机构)。在整个世界上绝对是独一无二的，SPF18BRR中的狒狒有一个 广泛的生物排斥清单，列出了通常在其他野生和圈养非人类灵长类动物中发现的18种病原体 殖民地。SPF18BRR将多个组件集成到一个旨在满足需求的计划中 利用其资源的调查人员。在拟议的支助期内，SPF18BRR将继续 为了改善它为用户提供的资源，并将继续添加有关生物和 脱毒狒狒对其网站的研究价值。狒狒仍然是人类的重要动物模型 基因工程猪异种移植是人类呼吸道合胞病毒唯一的NHP模型 和百日咳，它们仍然是细菌性败血症的一个非常重要的模型。此外，狒狒也是 人类COVID相关性肺炎的优秀模型，它们在人类COVID相关性肺炎的发展中发挥了重要作用 批准的SARS CoV-2疫苗。未来五年，SPF18BRR将专注于扩大 满足当前和未来生物医学研究需要的SPF18狒狒繁育群体 无病毒橄榄狒狒。SPF18BRR的资源部分的总体目标是继续 扩大和多样化SPF18橄榄狒狒和橄榄狒狒的国家级研究资源 生物材料；为科学家、兽医、殖民地管理人员和 与无病毒的狒狒一起工作的动物照顾者；以及支持需要设施和 使用SPF18狒狒进行研究的专业知识。新的研究领域不断涌现，需要 仅在过去的几年里，狒狒就已经成为人类的优秀模型。 阿尔茨海默病和相关痴呆症，并作为人类SARS冠状病毒-2感染的优秀模型。AS 随着这些和其他新的研究领域的发展，SPF18BRR在为动物提供 生物资源，以及支持这些研究项目所需的专门知识。在接下来的五年， SPF18BRR将继续向科学界提供SPF18狒狒和相关资源，并 将继续增加SPF18狒狒作为生物医学研究模型的价值。目前， 对甲苯和生物资源的需求远远超出了我们提供动物和资源的能力 为了满足这一需求，NIH必须继续支持这一独特的生物医学研究 资源。

PROJECT SUMMARY: RESOURCE COMPONENT The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated a number of components into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of human respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs for adventitious virus free olive baboons. The overall goals of the Resource Component of the SPF18BRR are to continue to expand and diversify the national research resource of SPF18 olive baboons and olive baboon derived biological materials; to provide education and training to scientists, veterinarians, colony managers, and animals caregivers who work with virus free baboons; and to support investigators who need facilities and expertise to conduct studies using SPF18 baboons. New areas of research continue to emerge that need SPF18 baboons: over the last few years alone the baboon has emerged as an excellent model of human Alzheimer’s disease and related dementias, and as an excellent model of human SARS CoV-2 infection. As these and other new areas of research develop, the SPF18BRR plays an essential role in providing animals, biological resources, and the expertise needed to support these research projects. Over the next five years, the SPF18BRR will continue to provide SPF18 baboons and related resources to the scientific community and will continue to increase the value of the SPF18 baboon as a model for biomedical research. Currently the demand for SPF18 baboons and biological resources far exceeds our ability to provide animals and resources to meet this need, which makes it imperative that NIH continue to support this unique biomedical research resource.