Training in Clinical and Basic Neuroscience

摘要 以密歇根大学医学院神经病学和神经外科系为中心， 翻译神经科学的长期培训计划包括跨 大学该计划的导师培训基础科学家和临床科学家进行研究， 神经系统疾病的翻译连续体，从基本的机械工作，通过临床前和 临床研究虽然在既定调查人员的指导下进行的指导研究是中心支柱， 在该计划中，一项新的“指导导师”倡议将支持有前途的年轻导师， 由一对高级研究员指导。此外，还将设立一个新的导师培训方案， 由NIH资助的国家研究指导网络设计，将使初级和高级导师受益 一模一样。我们的学员的指导研究经验是由适当的正规教育和 核心计划旨在提供严格的定量和生物统计培训，扩大学员的 知识超越他们狭隘的研究重点，并确保成功的职业发展。之一 该计划的优势是其临床和基础科学培训的整合：实验室科学家是 通过他们的同事和导师在节目中接触临床问题，临床研究人员获得了 通过他们的基础科学接触，更好地了解疾病的机制。基于实验 研究培训采用面向项目的方法，由导师认真指导。学员 临床科学课程能够完成硕士学位，如公共卫生学院的 临床研究硕士课程，但并不要求所有参与者都有正式学位。学员包括 无论是生物医学博士科学家谁寻求以疾病为导向的神经科学的培训，和临床医生-主要是 神经学家和神经外科医生-谁已经完成了临床培训，并选择追求一个 实验室或临床研究职业生涯。他们是由该计划的执行人员通过竞争挑选出来的 理事会。招聘流程包括通过桥梁连接的强有力的多元化外展计划 NINDS赞助的旨在增加神经科学研究生和 研究生教育。这个培训项目是嵌入在大学的丰富的研究 环境，其中包括一个高度学院和跨学科的神经科学研究社区，优秀的 生物医学研究的核心资源，以及转化和临床研究的强大资源。我们事先 受训人员在神经科学领域取得了很大成功， 我们每年都被迫拒绝优秀的申请人。我们建议继续把受训人数定为五人 博士后研究员每年，与每个实习生在该计划的1-2年取决于他们的成功， 获得外部资金。

Abstract Centered in the Departments of Neurology and Neurosurgery at the University of Michigan Medical School, this longstanding training program in Translational Neuroscience includes additional stakeholders across the University. The program’s preceptors train basic scientists and clinician-scientists to conduct research in neurological diseases across the translational continuum, from basic mechanistic work through preclinical and clinical research. While mentored research under the direction of established investigators is the central pillar of this program, a new “mentoring the mentor” initiative will support promising younger preceptors with guidance from a paired senior investigator. In addition, a new mentor training program will be instituted, as designed by the NIH-funded National Research Mentoring Network, that will benefit junior and senior mentors alike. Our trainees’ mentored research experiences are complemented by appropriate formal education and a Core Program designed to provide rigorous quantitative and biostatistical training, expand the trainees’ knowledge beyond their narrower research focus, and ensure successful career progression. One of the strengths of this program is its integration of clinical and basic science training: laboratory scientists are exposed to clinical issues via their colleagues and mentors in the program, and clinical researchers gain a better understanding of the mechanisms of disease via their basic science exposures. Laboratory-based research training follows a project-oriented approach, with careful mentoring by the preceptors. Trainees in clinical science programs are able to complete a Master’s Degree, such as the School of Public Health’s Master’s Program in Clinical Research, but a formal degree is not required of all participants. Trainees include both biomedical PhD scientists who seek training in disease-oriented neuroscience, and clinicians – principally neurologists and neurosurgeons - who have completed clinical training and have chosen to pursue a laboratory-based or clinical research career. They are selected competitively by the program’s Executive Council. The recruitment process includes a strong diversity outreach initiative connected by a bridging program to NINDS-sponsored programs aimed at increasing diversity in Neuroscience graduate and postgraduate student education. This training program is embedded within the University’s rich research environment which includes a highly collegial and interdisciplinary neuroscience research community, excellent core resources for biomedical research, and strong resources for translational and clinical research. Our prior trainees have been very successful in moving on to and establishing productive careers in neuroscience, and we are forced to turn away excellent applicants every year. We propose to continue our trainee number at five postdoctoral fellows per year, with each trainee in the program for 1-2 years depending on their success in obtaining external funding.