Collaborative Approach for Asian Americans, Native Hawaiians, and Pacific Islanders Research and Education (CARE) 2.0

项目摘要/关怀摘要2.0 尽管亚裔美国人是美国增长最快的种族人口， 夏威夷原住民和太平洋岛民(AANHPI)在 研究。例如，在国家阿尔茨海默氏症协调中心，只有不到3%的参与者 中心数据库是AANHPI个人，更少的人参加了 前景看好的疗法。研究和教育的协作方法(CARE) 注册表(R24 AG063718)是为改进AANHPI表示而构建的美国多语言注册表 在阿尔茨海默病和相关痴呆症(ADRD)、衰老和照顾方面的研究。 CARE于2020年10月推出，已招募了9405名AANHPI成年人(截至10月2日)，其中包括 55.9%的人英语水平有限，80.9%的人以前没有参与过研究 经验。CARE已经向5,500多名参与者推荐了27项正在进行的各种研究 招募和完成学习的阶段。作为关键的下一步，在NIA Health的指导下 差异框架，我们建议CARE 2.0从战略上扩大注册，推进 AANHPI参与者招募和留住的科学，并检查影响因素 与转介的注册参与者中的研究登记决定有关。我们的特定 目的包括：1)在10,000名新的不同队列中调查人们对健康研究的态度 在美国招募AANHPI成年人；2)从CARE获得观点和建议 与会者关于注册表保留，并制定、实施和评估建议 登记处保留战略。将使用闪电报告方法进行动态 定性数据分析和快速综合调查结果，以便进行快速比较分析 跨群体和环境，制定对不同需求敏感的目标策略 保留AANHPI参与者；以及3)优化护理登记参与者纳入NIA- 资助和其他老龄化研究，并检查包括研究和参与者水平在内的因素 与参与研究有关的因素。这些创新的目标将增加和检验 护理登记处的价值，并更广泛地告知外地如何最好地增加 AANHPI群体在研究中的代表性。CARE处于有利地位，能够实现这些目标 并为日益增长的招聘和留住科学做出贡献。这项建议的应用程序是 响应PAR-22-093(ADRD当前主题研究)和NOT-AG-21-033(通知 特别关注：健康差距和阿尔茨海默病)。

Project Summary/Abstract of CARE 2.0 Despite being the fastest growing racial population in the United States, Asian American, Native Hawaiian, and Pacific Islander (AANHPI) persons remain severely underrepresented in research. For example, less than 3% of participants in the National Alzheimer's Coordinating Center database are AANHPI individuals and even fewer are enrolled in clinical trials of promising therapeutics. The Collaborative Approach for Research and Education (CARE) registry (R24 AG063718) is a US multi-lingual registry built to improve AANHPI representation in Alzheimer’s disease and related dementias (ADRD), aging, and caregiving research. Launched in October 2020, CARE has enrolled 9,405 AANHPI adults (as of 10/2/22) including 55.9% with limited English proficiency and 80.9% with no prior research participation experience. CARE has referred more than >5,500 participants to 27 studies that are in various stages of recruitment and study completion. As a critical next step and guided by the NIA health disparities framework, we propose CARE 2.0 to strategically expand the registry, advance the science of recruitment and retention of AANHPI participants, and examine the factors associated with research enrollment decisions among referred registry participants. Our specific aims include: 1) Examine attitudes toward health research in a diverse cohort of 10,000 newly recruited AANHPI adults in the US; 2) Elicit perspectives and recommendations from CARE participants about registry retention, and develop, implement, and evaluate recommended registry retention strategies. The Lightning Report Method will be used to conduct dynamic qualitative data analysis and rapid synthesis of the findings to allow rapid comparative analyses across groups and contexts to derive targeted strategies that are sensitive to the diverse needs of retaining AANHPI participants; and 3) Optimize CARE registry participants’ inclusion in NIA- funded and other aging studies and examine factors including study- and participant-level factors associated with participation in research. These innovative aims will increase and test the value of the CARE registry and inform the field more broadly on how best to increase representation of AANHPI groups in research. CARE is well-positioned to complete these aims and contribute to the growing science of recruitment and retention. This proposed application is responsive to PAR-22-093 (Research on Current Topics in ADRD) and NOT-AG-21-033 (Notice of Special Interest: Health Disparities and AD).