Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research Unit

项目总结 尽管五岁以下儿童死亡率(U5MR)和新生儿死亡率有所改善 在印度儿童(核磁共振)中，死亡的负担在这一人群中仍然是活产儿对死亡者。要实现 对于联合国可持续发展目标的U5MR和NMR率，仍有迫切需要 在印度和全球通过儿童保育改善孕前状况。的首要目标是 波士顿大学(BU)和拉塔医学研究基金会(LMRF)全球妇女网络(GN) 和儿童健康研究组(RU)将继续与其他GN RU合作研究 改善低收入和中低收入国家妇女和儿童的健康状况。我们有 自2008年以来，一直在印度那格浦尔拥有GN RU。我们的俄亥俄州位于俄亥俄州东部 马哈拉施特拉邦(印度中部)，核磁共振和婴儿死亡率高于 邦和印度的许多其他地区。我们的RU涉及多个学校和部门之间的伙伴关系 (特别是全球卫生、产科、儿科和传染病) 由位于那格浦尔的LMRF领导的学术医疗机构联盟，提供临床和研究专业知识 和基础设施支持。自2008年以来，我们的RU成功地实施了研究，由患者和 公众参与和参与战略，体现了全球网络开展高影响力 可持续、成本效益高的卫生干预措施的临床试验和观察性研究 在小岛屿发展中国家的妇女和儿童中实施，并建设可持续的专业能力和 传染病(孕产妇和儿科)、产科、新生儿和儿科研究的基础设施。在 在当前这一周期中，我们参加了所有共同议定书，并保持了较高的征聘人数 和保留率。我们领导了5个研究项目，包括建立一个新的社会经济地位 指数，并研究与接触铅有关的孕产妇、胎儿和新生儿不良后果的风险。 家庭空气污染、剖腹产和产妇抑郁。我们也有一个领导层 在阿奇霉素试验子研究中的作用使用新的微生物群获得阿奇霉素耐药性的风险， 元基因组学和全基因组测序方法，这需要帮助发展实验室能力 几个GN站点。我们联合并成功地指导了20名初级教职员工、研究员和学生 LED站点特定和GN范围内的出版物。继续壮大和发展那格浦尔RU，推动 该地区的研究网络，并为设计和实施公共研究基础设施提供支持 那格浦尔学术机构的卫生研究；加强侧重于以下主要原因的研究 GN和那格浦尔地区的怀孕和儿童早期发病率和死亡率 患者参与；并继续找出和解决孕产妇和儿童研究中的差距。

PROJECT SUMMARY Although there have been improvements in the under age five mortality rate (U5MR) and neonatal mortality rate (NMR) in Indian children, the burden of death in this population is still one live births to deaths. To achieve the United Nations Sustainable Development Goals for the U5MR and NMR rate, there is still an urgent need for improvement in pre-pregnancy through childhood care in India and globally. The overarching goal of Boston University (BU) and Lata Medical Research Foundation's (LMRF) Global Network (GN) for Women's and Children's Health Research Unit (RU) is to continue to collaborate with other GN RUs on research to improve health outcomes for women and children in low- and lower middle-income countries (LMIC). We have had a GN RU in Nagpur, India continuously since 2008. Our RU is in the eastern part of the State of Maharashtra (center of India) where NMR and infant mortality rates are higher than the overall rates in the state and many other parts of India. Our RU involves a partnership between multiple Schools and Departments (particularly Global Health, Obstetrics, Pediatrics, and Infectious Diseases) at Boston University and the academic medical institutional consortium led by the LMRF in Nagpur, that provides clinical, research expertise and infrastructure support. Since 2008, our RU has been successfully implementing studies, by patient and public involvement and engagement strategy, that exemplify Global Network's goals to conduct high-impact clinical trials and observational studies of sustainable, cost-effective health interventions and their implementation in women and children in LMICs, and building sustainable professional capacity and infrastructure for infectious diseases (maternal and pediatric), obstetric, neonatal and pediatric research. In the current cycle of the GN, we have participated in all common protocols, and have maintained high recruitment and retention rates. We have led 5 research initiatives, including developing a new socioeconomic status index, and studying the risk of maternal, fetal and neonatal adverse outcomes associated with exposure to household air pollution, Caesarian Section delivery and Maternal Depression. We have also had a leadership role in the Azithromycin trial sub-study on risk of acquiring Azithromycin resistance using novel microbiome, metagenomics and whole genome sequencing approaches, which required helping develop lab capacity in several GN sites. We have jointly and successfully mentored 20 junior faculty, fellows and students who have led site specific and GN wide publications. continue growth and development of the Nagpur RU, advance the research network in the region, and sustain the research infrastructure for the design and conduct of public health research in the Nagpur academic institutions; strengthen research focused on the leading causes of morbidity and mortality in pregnancy and early childhood in the GN and in the Nagpur area by public and patient engagement; and continue to identify and address gaps in maternal and child research.