Multidisciplinary Schizophrenia Research Training

项目摘要 这是马里兰州精神病学研究中心第三次竞争性更新T32培训补助金 (MPRC)，最初于2003年获得资助(MH067533)。该计划的目标是培养医学博士、博士 对基础或临床研究感兴趣的药学人员，从事心理健康领域的翻译研究 关注精神分裂症和精神疾病相关的疾病。MPRC，一个有组织的研究中心 马里兰大学医学院和精神病学系，是一所最先进的 位于春林的精神分裂症及相关疾病研究中心 医院中心，位于巴尔的摩郊外的马里兰州住院精神卫生机构。MPRC 研究涉及广泛的综合和翻译科学，以研究特定的病理 与精神分裂症和相关疾病有关，包括：神经生理学、神经成像、基础 神经化学，啮齿动物和小型猪的电路模拟，疾病病因学，领域 精神病理学和内表型、神经认知、实验治疗学和临床试验。这个 MPRC的协作框架30多年来一直支持NIMH P50奖项，最近一次是CIDAR 目前正在西尔维奥·奥孔特中锋的第6年(2019年秋季)。MPRC的特点是连续 临床前和临床研究人员之间的互动和协作-我们共享相同的空间、研讨会 日程安排、教职员工会议和一般研究兴趣。这种综合体验为以下几个方面做了准备 MPRC的教职员工将积极支持NIMH研讨会为 RDoC倡议和本申请的一名PI是分配给RDoC单位的NIMH高级顾问。科学 与其他组件的广泛参与丰富了机会和协作 马里兰大学医学院和药学院以及附近的马里兰大学 巴尔的摩县(UMBC)。根据这一T32奖学金提供的博士后培训主要集中在 精神分裂症及相关疾病的基础神经科学和临床研究。所有受训人员都受过教育 关于MPRC的翻译观点，并在临床上提供指导和教学培训 精神病理学和基础神经科学，以及有条理的职业规划。我们的独特之处在于我们拥有 广泛的多学科培训机会(我们唯一接受药学)以及 将以非研究为重点的临床人员整合到课程中，以培训科学家在实用、真实 世界对该领域的需求。MPRC的文化为我们在招聘和管理方面的成功奠定了基础 为从事科学事业培训博士后研究员，包括临床科学家。该项目的毕业生领导 富有成效的、成功的研究密集型职业。这份竞争激烈的五年期续订申请建议 利用我们之前的成功，继续改进我们的培训方法(包括导师培训)，以 培养多产的、全面发展的、专注于翻译的科学家。

Project Summary This is the third competitive renewal of a T32 training grant at the Maryland Psychiatric Research Center (MPRC), originally funded in 2003 (MH067533). The goal of the proposed program is to prepare MDs, PhDs and PharmDs interested in basic or clinical research for a career in translational research in mental health with a focus on schizophrenia and psychosis-related disorders. The MPRC, an Organized Research Center of the University of Maryland School of Medicine and division of the Department of Psychiatry, is a state-of-the-art center for research on schizophrenia and related disorders, located on the grounds of the Spring Grove Hospital Center, a State of Maryland inpatient mental health facility located just outside Baltimore. MPRC research engages a broad range of integrated and translational science to investigate specific pathologies associated with schizophrenia and related disorders including; neurophysiology, neuroimaging, basic neurochemistry, circuitry modeling in rodents and miniature pigs, disease etiology, domains of psychopathology and endophenotypes, neurocognition, experimental therapeutics and clinical trials. The MPRC’s collaborative framework has supported NIMH P50 awards for over 30 years, most recently a CIDAR and presently in year 6 of a Silvio O. Conte Centerr (Fall 2019). The MPRC is characterized by continuous interaction and collaboration among preclinical and clinical investigators- we share the same space, seminar schedules, faculty meetings and general research interests. This integrated experience prepared several faculty at MPRC to take an active role in supporting NIMH workshops developing behavioral constructs for the RDoC initiative and one PI on this application is a senior advisor to NIMH assigned to the RDoC Unit. Scientific opportunities and collaborations are enriched with extensive involvement with other components of the University of Maryland School of Medicine and School of Pharmacy and the nearby University of Maryland Baltimore County (UMBC). Postdoctoral training offered under this T32 fellowship has a primary focus on both basic neuroscience and clinical investigations of schizophrenia and related disorders. All trainees are educated on the translational perspective of the MPRC and provided mentors and didactic training in both clinical psychopathology and basic neuroscience as well as structured career planning. We are unique in that we have a broad array of opportunities for multidisciplinary training (we uniquely accept PharmDs) as well as having nonresearch focused clinical personnel integrated in the curriculum to training scientists in pragmatic, real world needs of the field. The culture at the MPRC provides the foundation for our success in recruiting and training post-doctoral fellows for a scientific career, including clinician scientists. Graduates of the program lead productive, successful research-intensive careers. This competitive five-year renewal application proposes to leverage our previous success and continue to improve our training approach (including mentor training) to produce productive, well-rounded translationally-focused scientists.