Utah Children's Project

项目摘要/摘要 对早期暴露的全面评估需要对曝光组进行多维评估， 包括社区一级的环境因素(如空气污染)、化学品暴露(如 内分泌干扰物)，社会因素(文化和家庭背景)，以及基因组及其对 环境(遗传表观基因组、基因组表达和蛋白质组)。犹他州儿童项目 7年来，UCP一直是犹他州为ECHO Cohort财团做出贡献的地点。UCP遵循 493个家庭单元中最多2名儿童和至少1名亲生父母的暴露和结局状况 招募计划怀孕的夫妇和怀孕的人。在UG3阶段(头两年)， 在整个队列的发展过程中，将继续进行先入为主和怀孕登记 与其他联合体网站合作制定的先入为主的协议。UCP还将继续保留 以及对之前登记的家庭进行后续调查。未孕和妊娠期间的暴露评估 Period是一个专门的站点重点领域。在UH3阶段，先入为主和怀孕登记将 继续特别重视来自代表性不足的少数族裔人口的犹他州家庭(例如，土著 夏威夷人或其他太平洋岛民、西班牙裔)，目标是通过实施 ECHO 3.0协议的所有方面，同时保持历史上最高的队列保留率。研究问题 有待研究的内容包括：(1)亚生育与母体代谢状况、生育治疗、 母乳喂养和后代哮喘，(2)室内空气质量与围产儿结局的关系， (3)纵向先入为主的暴露组混合物与围产儿结局。与流程相关的目标是重新- 在UG3阶段注册和保留至少95%的当前注册儿童，并通过 UH3阶段，同时实现高保真和高响应率的ECH3.0协议。

PROJECT SUMMARY / ABSTRACT A comprehensive assessment of early exposures requires a multidimensional assessment of the exposome, including community-level environmental factors (such as air pollution), chemical exposures (such as endocrine disruptors), social factors (cultural and family context), and the genome and its responses to the environment (inherited epigenome, genomic expression, and the proteome). The Utah Children’s Project (UCP) has been the Utah site contributing to the ECHO Cohort consortium for 7 years. The UCP follows the exposure and outcome status of up to 2 children and at least 1 biological parent in 493 family units as well as enrolls couples planning pregnancy and pregnant people. In the UG3 Phase (the first two years), preconception and pregnancy enrollments will continue during the development of the cohort-wide preconception protocol in partnership with the other consortium sites. The UCP will also continue with retention and follow-up of families previously enrolled. Exposure assessment during the preconception and pregnancy periods is a specialized site focus area. In the UH3 Phase, preconception and pregnancy enrollments will continue with particular emphasis on Utah families from underrepresented minority populations (eg, Native Hawaiian or Other Pacific Islander, Hispanic), with a goal of up to 600 new enrollments with implementation of all aspects of the ECHO 3.0 protocol while maintaining a historically high cohort retention. Research questions to be investigated include (1) the relationship between subfertility, maternal metabolic status, fertility treatment, breastfeeding, and asthma in offspring, (2) the relationship between indoor air quality and perinatal outcomes, and (3) longitudinal preconception exposome mixtures and perinatal outcomes. A process-related aim is to re- enroll and retain at least 95% of currently enrolled children throughout the UG3 Phase, and 90% through the UH3 phase while implementing the ECHO 3.0 protocol with high fidelity and response rates.