MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)

项目总结 医生-科学家通过身份识别在弥合基础科学和临床医生之间的鸿沟方面发挥着独特的作用 重要的临床问题和转化结果，以改善患者护理。令人遗憾的是，医生-科学家队伍 继续减少，这可能会导致生物医学研究中的负面、长期后果。许多派驻人员 课程的重点是获取医学知识，而不是培养求知欲和入门知识 进入生物医学研究领域。进一步削弱人们对内科科学家职业兴趣的是有能力 找出一位鼓舞人心的成功导师。迫切需要重新强调对现有医生的重视- 科学家是实习生的榜样。在这项建议中，我们的目标是提高吸引力，并为职业生涯做好准备 住院医师培训期间的医生-科学家。阿尔茨海默病和相关痴呆(ADRD)、虚弱和 老龄化中的多发病是科学的基本领域，它极大地受益于强大的医生-科学家队伍。 该培训项目的总体目标是提高人们对老年疾病的兴趣和准备。 未来医生-科学家通过提供坚实的基础培训来解决人口老龄化面临的问题 居民成为多产的独立科学家，他们可以在从基础科学到 临床调查。为此，我们建议实施马萨诸塞州综合医院疾病 通过刺激住院研究(MGH DAP STARR)计划实现老龄化途径。该计划将培训 新内科医生--整个生物医学研究过程中的科学家，他们将促进新的预防和治疗 应对老龄化相关疾病的措施。MGH DAP STARR计划围绕以下四个目标展开： 通过强有力的纵向指导参与创造重要的科学贡献，重点是 领导要领；[2]开发必要的实验室、转化性或临床研究方法，以进行高 相关老龄化领域的高质量研究；[3]制定基于假设的研究问题、开发和执行 在NIA的大力指导下，有效地交流他们科学的意义-- 资助研究人员；以及[4]为ADRD作为独立内科科学家的持续发展建立一条途径， 虚弱，以及衰老中的多发病。MGH DAP STARR计划将允许来自医学部的两名住院医生 在MGH或希伯来语马库斯老龄研究所进行为期12-24个月的研究 老年高级生命研究所。该项目将由克里斯汀·里奇(医学)、布拉德利·海曼(神经病学)、 和Jatin Vyas(医学实习计划主任)，内部指导委员会和外部咨询委员会， 与一起，多学科和NIA资助的研究导师。总之，这些计划旨在吸引、 培训和留住医学博士，从事ADRD、虚弱和老龄化多发病领域的生物医学研究。 他们职业生涯中最关键的关头--实习培训。

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Regrettably, the physician-scientist workforce has continued to diminish, which may lead to negative, long-lasting consequences in biomedical research. Many residency programs focus heavily on acquiring medical knowledge as opposed to fostering intellectual curiosity and an introduction into the biomedical research field. Furthering the diminishing interest in a career as a physician-scientist is the ability to identify an encouraging and successful mentor. There is a critical need for a renewed emphasis on established physician- scientists as role models to trainees. In this proposal, we aim to enhance attractiveness and preparedness for a career as a physician-scientist during residency training. Alzheimer’s disease and related dementias (ADRD), frailty, and multimorbidity in aging are fundamental areas of science that greatly benefit from a robust physician-scientist workforce. The overall goal of this training program in ADRD, frailty, and multimorbidity in aging is to raise interest and preparedness of future physician-scientists to tackle the problems facing the aging population by providing a solid foundation to train residents to be productive, independent scientists who can advance studies in a broad range of areas from basic science to clinical investigation. To this end, we propose the implementation of the Massachusetts General Hospital Diseases of Aging Pathway via Stimulating Access to Research in Residency (MGH DAP StARR) program. The program will train new physician-scientists throughout the biomedical research continuum who will promote new preventative and therapeutic measures for aging-related diseases. The MGH DAP StARR program is centered around the following four objectives: [1] engage in the creation of important scientific contributions through strong, longitudinal mentorship with an emphasis on leadership essentials; [2] develop laboratory, translational, or clinical research approaches necessary to conduct high- quality research in pertinent areas of aging; [3] formulate hypothesis-based research questions, development and execution of a research project, and effectively communicate the significance of their science with intense mentorship from NIA- funded investigators; and [4] establish a pathway for continued development as independent physician-scientists in ADRD, frailty, and multimorbidity in aging. MGH DAP StARR program will allow two residents from the Departments of Medicine and Neurology at MGH to conduct research for 12-24 months at MGH or the Marcus Institute of Aging Research at Hebrew Senior Life Institute of Aging. The program will be co-led by Christine Ritchie (Medicine), Bradley Hyman (Neurology), and Jatin Vyas (Medicine Residency Program Director), an Internal Steering Committee, and External Advisory Board, along with 64 multidisciplinary and NIA-funded research preceptors. Together, these initiatives are designed to attract, train, and retain MDs in biomedical investigation in the areas of ADRD, frailty, and multimorbidity in aging at the most critical juncture of their career - residency training.