课题基金 / 基金详情

Assay optimization and screening for measuring the kinetics of antibacterial resistance emergence

Assay optimization and screening for measuring the kinetics of antibacterial resistance emergence
用于测量抗菌药物耐药性出现动力学的测定优化和筛选
批准号：
10919706
负责人：
Anton Simeonov
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10919706
关键词：
AddressAntibiotic ResistanceBacterial Drug ResistanceBacterial InfectionsBiological AssayClinicalCombined Modality TherapyDrug CombinationsDrug KineticsDrug resistanceFiberInfectionKineticsLiquid substanceMeasuresModelingNational Center for Advancing Translational SciencesPharmaceutical PreparationsPublic HealthSystemminiaturizeresponsescreening

项目摘要

项目成果

Anton Simeonov的其他基金

相似基金

相关文献

中文摘要
翻译
抗生素耐药性是当今公共卫生的主要威胁之一。要解决这一问题，需要采取紧急的综合办法。策略和多靶点联合治疗已越来越多地用于临床治疗细菌感染。FDA的合作者已经开发了一种中空纤维感染模型来评估药物联合（2和3种药物）耐药性的出现，然而，这在其吞吐量上是有限的。为了解决这个问题，项目团队正在利用NCATS的液体处理能力来筛选细菌对药物组合的反应，并测量耐药性出现的动力学。
英文摘要
Antibiotic resistance is one of the major threats to public health today. To address this problem requires an urgent comprehensive approach. Strategic and multi-targeted combination therapy has been increasingly used clinically to treat bacterial infections. Collaborators at the FDA have developed a hollow-fibre infection model to assess the emergence of drug resistance in response to drug combinations (2 and 3 drugs), however, this is limited in its throughput. To address this, the project team is leveraging NCATS's liquid handling capabilities to screen bacterial responses to combinations and measure the kinetics of the emergence of drug resistance.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PRKACA for Fibrolamellar hepatocellular carcinoma
MST/ITC studies on Vimentin DHA interaction
Disrupting Type IV secretion function to prevent virulence in the pathogenic bacterium Legionella pneumophila
High-throughput multiparametric drug screening method for 3D spheroids
海外基金