DEVELOPMENT OF UM-1098: A NOVEL SYNTHETIC TH17 INDUCING ADJUVANT AND DELIVERY SYSTEM

迫切需要开发和临床评价安全有效的Th 17诱导佐剂，以促进疫苗对抗细菌和真菌病原体的持续威胁，所述细菌和真菌病原体包括结核分枝杆菌（Mtb）、百日咳博德特氏菌、金黄色葡萄球菌、铜绿假单胞菌、肺炎链球菌、白色念珠菌、烟曲霉等。针对TB和其他细菌和真菌病原体的疫苗接种由于缺乏用于诱导Th 17免疫的适当佐剂而受到阻碍。因此，能够诱导针对新出现的细菌和真菌病原体的广泛保护性免疫应答的下一代疫苗佐剂代表了关键的未满足的需求。这项佐剂开发合同将推进一种这样的佐剂- UM-1098：一种诱导Th 17的合成Mincle配体-用于人体临床试验。UM-1098是通过NIAID佐剂发现计划通过全面和迭代的结构-活性关系（SAR）研究鉴定的，以鉴定与新型纳米颗粒递送系统配对的新型合成二芳基海藻糖Mincle受体配体。该佐剂和递送系统在小鼠、猪和非人灵长类动物（NHP）中具有良好的安全性和有效性特征，涵盖多种高度相关的抗原/病原体平台，包括TB和百日咳杆菌。UM-1098相对于先前开发的Mincle佐剂的优势包括改进的制剂理化性质、热稳定性、稳健的安全性，最重要的是，在啮齿动物、猪和NHP中具有上级的抗原特异性Th 17、Th 1和体液免疫。当与抗原共同施用时，UM-1098佐剂诱导持久的细胞介导的和体液免疫，具有针对Mtb和百日咳博德特氏菌攻击的保护作用。

The development and clinical evaluation of safe and effective Th17 inducing adjuvants is urgently needed for the advancement of vaccines to combat the ongoing threat of bacterial and fungal pathogens including Mycobacterium tuberculosis (Mtb), Bordetella pertussis, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia, Candida albicans, Aspergillus fumigatus and others. Vaccination against TB and other bacterial and fungal pathogens has been hampered by the lack of appropriate adjuvants for inducing Th17 immunity. Thus, the next generation of vaccine adjuvants capable of inducing broadly protective immune responses against emerging bacterial and fungal pathogens represents a critical unmet need. This Adjuvant Development Contract will advance one such adjuvant – UM-1098: a Th17 inducing synthetic Mincle ligand– towards human clinical trials. UM-1098 was identified through the NIAID Adjuvant Discovery Program via a comprehensive and iterative structure-activity relationship (SAR) investigations to identify a novel synthetic diaryl trehalose Mincle receptor ligand paired with a novel nanoparticle delivery system. This adjuvant and delivery system has a well-established safety and efficacy profile in mice, pigs and non-human primates (NHPs) across multiple highly relevant antigen/pathogen platforms including TB and Bordetella pertussis. The advantages of UM-1098 over previously developed Mincle adjuvants includes improved formulation physiochemical properties, thermostability, robust safety profile, and most importantly, superior antigen-specific Th17, Th1, and humoral immunity across rodents, pigs and NHPs. When co-administered with an antigen, UM-1098 adjuvant induces durable cell-mediated and humoral immunity with demonstrated protection against Mtb and Bordetella pertussis challenge.