DATA COORDINATING CENTER TO PROVIDE SERVICES TO WORK COLLABORATIVELY WITH THE NATIONAL NEUROHIV TISSUE CONSORTIUM CLINICAL SITES TO PROVIDE MANAGEMENT AND DATABASE CAPABILITIES, SCIENTIFIC EXPERTISE,

目前由NIMH，NINDS，NIDA和NIA资助的国家神经HIV组织联盟（NNTC）最初成立于1998年，旨在收集，储存和分发从HIV阳性和阴性患者中收集的中枢和外周神经系统组织，脑脊液，血液和其他器官（如心脏，肺，肝脏和肾脏）的样本，支持世界各地的研究人员谁希望追求健全的研究项目，并进一步我们的神经艾滋病病毒疾病的知识。除了脑库操作，临床研究中心还跟踪并收集来自活跃的HIV阳性患者队列的死前数据，包括广泛的神经行为电池，包括神经心理学测试和精神病学评估、神经医学评价、实验室结果以及用于毒理学和样本库的液体样本采集。新的研究中心合同将包括对现有数据收集方案的修订，增加新的RDoC评估、神经成像、生物标志物检测以及对各种神经行为电池的更新。在死后对脑、脊髓和外周器官进行详细的病理学评估，然后根据严格的既定方案对样本进行储存，以确保四个临床研究中心的一致性。根据目前的合同，NNTC的DCC的任务是作为中央数据库，监测研究中心对研究方案和SOP的遵守情况，并提供数据管理，生物统计和生物信息支持，使临床研究中心能够有效地对标本和临床数据进行分类和维护，同时促进与更广泛的科学界共享资源。

The National NeuroHIV Tissue Consortium (NNTC), currently funded by NIMH, NINDS, NIDA, and NIA, was originally established in 1998 to collect, store, and distribute samples of central and peripheral nervous system tissue, cerebrospinal fluid, blood, and other organs such as heart, lung, liver, and kidney collected from HIV positive and negative patients, to support researchers around the world who wish to pursue sound research projects and further our knowledge of neuroHIV disorders. In addition to brain banking operations, the clinical sites follow and collect ante-mortem data from an active cohort of HIV positive patients including an extensive neurobehavioral battery including neuropsychological testing and psychiatric assessments, neuromedical evaluation, laboratory results, and fluid sample collection for toxicology and sample banking. The new site contract will include revisions to the existing data collection protocol adding new RDoC assessments, neuroimaging, biomarker testing, and updates to various neurobehavioral battery. Detailed pathological evaluations of brain, spinal cord, and peripheral organs are conducted post-mortem and samples are then banked according to strict established protocols to ensure uniformity across the four clinical sites. The DCC for the NNTC under the current contract is tasked with serving as the central data repository, monitoring site adherence to study protocols and SOPs and providing data management, biostatistical and bioinformatic support to enable the clinical sites to effectively catalogue and maintain specimens and clinical data while also facilitating the sharing of resources with the broader scientific community.