Biospecimen Core

Biosecimen核：综述 Biospecimen Core是支持西北大学所有脑瘤研究的重要资源，并且是 尤其重要的是要确保所有项目都在孢子资助期内经历临床翻译。 与生物统计和生物信息学核心和管理核心的定期互动将确保每个 项目实现了目标，对脑肿瘤患者的护理产生了积极的影响。 Biosecimen核心将作为中心与所有项目和核心进行广泛的互动 通过提供最高质量的组织分析，存储患者组织和可更新的肿瘤资源 服务，并提供神经病理咨询。核心主任霍宾斯基博士以及 联席主任Daniel Brat博士将监督银行标本的质量控制测试，并将执行所有 对每个孢子项目的患者组织和肿瘤模型进行基于显微镜的分析。Biosecimen核 将开展活动以实现以下目标： 目的1：为西北脑肿瘤研究人员提供来自患者的注释生物标本。 目标2：对所有生物检验品进行严格的质量控制。 目的3：开展以生物素为基础的自主研究，研究脑肿瘤生物学，优化治疗方案 临床相关生物标志物的使用。 目的4：用生物标本和神经病理学分析来支持孢子项目。

BIOSPECIMEN CORE: SUMMARY The Biospecimen Core is a vital resource that supports all brain tumor research at Northwestern, and is especially important in seeing that all projects experience clinical translation within the period of SPORE funding. Regular interactions with the Biostatistics & Bioinformatics Core and Administrative Core will ensure that each project achieves its objectives, and has positive impact on the care of brain tumor patients. The Biospecimen Core will have extensive interactions with all projects and cores by acting as the central repository of patient tissues and renewable tumor resources, by providing the highest quality of tissue analytical services, and by providing neuropathological consultation. The Director of the Core, Dr. Horbinski, as well as the Co-Director, Dr. Daniel Brat, will supervise quality control testing of banked specimens, and will perform all microscopy-based analyses of patient tissues and tumor models for each SPORE project. Biospecimen Core activities will be performed to accomplish the following aims: Aim 1: Provide Northwestern brain tumor researchers with annotated biospecimens from patients. Aim 2: Subject all biospecimens to rigorous quality control. Aim 3: Conduct biospecimen-based independent research to study brain tumor biology and optimize the use of clinically relevant biomarkers. Aim 4: Support SPORE projects with biospecimens and neuropathologic analyses.