Workshop on Statistical Genetic Methods for Human Complex Traits

项目摘要 该提案要求再提供五年的资金，以支持组织和提供面对面和 虚拟强化培训讲习班侧重于统计，行为和 数量遗传学将推进NIMH的使命。四个研讨会将在一周内面对面进行 另一个将在两周内进行虚拟化。我们还要求提供资金，以支持开发一个网站 致力于自学这些材料，这将大大增加讲习班的覆盖面。的 讲习班及其相关网站针对博士后学员、研究生和医科学生， 早期职业教师目前正在进行或计划启动对心理健康遗传学的研究。到 为了平衡使用各种方法的研究人员的需求，我们的现场研讨会将交替进行 在关注双胞胎、家庭、多变量和发育数据的结构方程模型（ “潜在遗传学课程”），以及一个侧重于分析测量的基因组变异的研讨会，包括 序列数据（“分子遗传学课程”）。虚拟课程将涵盖这两个内容领域， 稍微多一点介绍性的重点。该网站将成为学习统计遗传学所有内容的中心枢纽 类型它将由视频讲座，实践，代码和相关阅读沿着论坛组成，所有 按主题组织并交叉引用。 通过教学和实践经验，参加讲习班的研究科学家将完善 他们在基因设计和分析方面的研究技能。该研讨会提供了一个创新的计划，旨在 提供教育，在国家的最先进的遗传学方法重要，以实现目前的目标， NIMH战略计划。虽然是为培训而设计的，但现场（面对面和虚拟）研讨会分享了一些 科学会议的特点。鼓励参与者讨论他们目前的研究， 他们的数据的副本直接工作，而在研讨会上，并讨论和制定研究计划。新 建立合作，以促进对现有数据集和新研究的高质量研究 讲习班上形成的协作加强了各项举措。其课程不断更新 世界领先的统计，行为和定量遗传学及其在心理健康中的应用。 该研讨会历来是行为，统计和 数量遗传学自1987年成立以来，它已登记约3，000人。很大一部分 一些关键词为“GWAS”和“孪生研究”的论文作者参加了研讨会， 该领域的领导者开始了他们的工作。拟议的研讨会形式（面对面，虚拟和在线） 代表着内容交付方式的现代化，并且已经在扩大覆盖范围方面取得了成果 和多样性。

PROJECT SUMMARY This proposal requests a further five years of funding to support the organization and delivery of in-person and virtual intensive training workshops focused on the development of skills in statistical, behavioral, and quantitative genetics that will advance the mission of NIMH. Four workshops will be in-person over one week and one will be virtual across two weeks. We also request funding to support the development of a website devoted to self-education of this material and that will greatly increase the reach of the workshop. The workshop and its associated website are targeted at post-doctoral trainees, graduate and medical students, and early career faculty currently conducting or planning to initiate research on the genetics of mental health. To balance the needs of investigators using a variety of methodologies, our in-person workshops will alternate between a focus on structural equation modeling of twin, family, multivariate, and developmental data (the “Latent Genetics Course”), and a workshop focusing on the analysis of measured genome variation including sequence data (the “Molecular Genetics Course”). The virtual course will cover both content areas with a slightly more introductory focus. The website will be a central hub for learning statistical genetics of all content types. It will be made up of video lectures, practicals, code, and relevant readings along with a forum, all organized by topic and cross-referenced. Through both didactics and hands-on experience, research scientists participating in the workshops will refine their research skills in genetic design and analysis. The workshop offers an innovative program designed to provide education in state-of-the-art genetic methodology important to fulfill the objectives of the current NIMH Strategic Plan. Although designed for training, the live (in-person and virtual) workshops share some characteristics of a scientific meeting. Participants are encouraged to discuss their current research, to bring copies of their data to work on directly while at the workshop, and to discuss and develop research plans. New collaborations are established to facilitate high quality research on existing data sets, and new research initiatives are strengthened by collaborations formed at the workshop. Its curriculum is continuously updated by world leaders in statistical, behavioral, and quantitative genetics and their applications to mental health. This workshop has historically been one of the most important gateways to behavioral, statistical, and quantitative genetics. It has logged ~3,000 registrations since its inception in 1987. A large proportion of authors of papers with keywords such as “GWAS” and “twin studies” have attended the workshop and many leaders in the field got their start at it. The proposed workshop formats (in-person, virtual, and online) represent a modernization of how content is delivered and have already born fruit in terms of increased reach and diversity.