ADVANCED SPIRAL CUFF ELECTRODE FABRICATION

描述(改编自申请者的摘要)：项目 目标是开发一种快速、可靠、可重现的 螺旋袖套神经电极的制造方法， 用于恢复神经受损个体的功能。是这样的 设备目前都是手工制作的，费力、不可靠 将铂箔切割并粘贴到硅橡胶上的工艺 并使用硬线进行互连。这项建议 致力于薄膜沉积技术的进一步发展，以 在硅橡胶上创建有图案的金属层，消除了 需要手工施工，并极大地提高了工艺产量和 产品可靠性。THING的可行性和原则性证明 胶片方法是在第一阶段建立的，一种快速、廉价的方法 使用个人计算机和激光打印机开发了图案化技术。 然后使用离子束辅助沉积(同上)来沉积极 在适当的图案中粘贴金属层。使用 已确定的拉伸硅胶片层压技术，导电 制备的电极具有理想的卷曲性和柔韧性。阶段 II将优化薄膜沉积条件，以进一步改善薄膜 延展性和导电性，并最大限度地减少引线宽度。与此相关的问题 电极的大规模生产，特别是在后处理金属中 将讨论制造过程中的沉积部分。 动物研究将被用来评估动物的重要特性 设备，如阈值功率电平、力的分级、短路和 长期稳定的募集性能，以及生物相容性。 这项评估将在多个中心进行，并将与各种 电极设计。

DESCRIPTION (Adapted from the applicant's abstract): The program objective is development of a rapid, reliable, and reproducible manufacturing process for fabrication of spiral cuff nerve electrodes, used to restore function in neurologically impaired individuals. Such devices are currently fabricated by hand in a laborious, unreliable process by cutting and gluing platinum foils to silicone rubber substrates and using hard wires for interconnects. This proposal addresses further development of thin film deposition technology to create patterned metallic layers on the silicone rubber, eliminating the need for hand construction and vastly increasing process yield and product reliability. The feasibility and proof-of-principle of the thin film approach were established in Phase I. A rapid, inexpensive method of patterning was developed using a personal computer and laser printer. Ion beam assisted deposition (IBID) was then used to deposit extremely adherent metallic layers in the appropriate pattern. Using the established stretched silicone sheet lamination technique, conductive electrodes with ideal curling and flexibility were fabricated. Phase II will optimize thin film deposition conditions to further improve film ductility and conductivity and minimize lead width. Issues surrounding mass production of the electrodes, particularly in the post-metal deposition portions of the fabrication process, will be addressed. Animal studies will be used to evaluate important properties of the devices, such as threshold power levels, grading of force, short and long-term stability of recruitment properties, and biocompatibility. This evaluation will take place at multiple centers and with various electrode designs.