DEMENTIA IN SWEDISH TWINS

双胞胎研究可以成为最重要的信息来源之一 关于环境和遗传因素在 阿尔茨海默病和其他痴呆症的病因学。 这 一项提案寻求对瑞典痴呆症研究的持续支持 双胞胎，以便对所有确定的 病例和合作伙伴在一致和不一致对，以确定 同一人群的事件病例，并获得前瞻性 来自民众的关于暴露于环境风险的信息， 痴呆症家族史和病史。 估计有60个病例 将纵向跟踪，预计将有30至40起事件 在研究期间， 纵向措施 包括认知成套测验和临床痴呆门控。 诊断 对事件案例的评估包括心理措施、医疗措施、 评估，神经影像学检查，和间接访谈 纵向病例 未受影响的伴侣将被要求参与尸检。 各种阈值或级联模型的病因和发病的 阿尔茨海默氏病似乎最有用的规划分析方法。 数据分析将包括： 和异卵双胞胎，责任阈值模型的应用， 估计环境和遗传的相对贡献 因素，使用logistic回归扩展病例对照模型， 包括多种风险，并使用定量遗传模型， 检查可能是痴呆症指标的表型分布 在他们的极端。 瑞典的样本提供了一个特殊的研究 有机会实现这些目标。

Twin studies can be one of the most important sources of information about the role of environmental as well as genetic factors in the etiology of Alzheimer's disease and other dementing illnesses. This proposal seeks continued support for the Study of Dementia in Swedish Twins, in order to conduct longitudinal follow-ups of all identified cases and partners in concordant and discordant pairs, to identify incident cases from the same population, and to obtain prospective information from the population about exposure to environmental risks, family history of dementia, and medical history. An estimated 60 cases will be followed longitudinally, with 30 to 40 incident cases anticipated during the period encompassed by the study. Longitudinal measures include a cognitive battery and a Clinical Dementia ]gating. Diagnostic assessment of incident cases includes psychological measures, medical evaluation, neuroimaging, and collateral interview. Longitudinal cases and unaffected partners will be requested to participate in an autopsy. Various threshold or cascade models for the etiology and onset of Alzheimer's disease seem most useful in planning analytic approaches. Data analyses will encompass: determining concordance rates for identical and fraternal twins, application of liability-threshold models to estimating the relative contribution of environmental and genetic factors, extension of case-control models using logistic regression to encompass multiple risks, and using quantitative genetic models to examine the distribution of phenotypes that may be indicators of dementia in their extreme. The Swedish sample provides a special research opportunity to achieve these purposes.