SJOGREN'S SYNDROME SYMPOSIUM

要求提供资金支持第二国际 将在奥斯汀举行的干燥综合征研讨会， 1988年10月23日至25日，德克萨斯州。 这次会议是一个机会 对于国际当局以及许多美国人来说， 风湿病学家讨论一种生物学上非常感兴趣的疾病， 牙科和医学。 本次会议的具体需求 从这种多因素疾病的自然史中得出， 引起了基础医学界的极大兴趣， 牙科科学家和临床医生代表几个 不同的学科。 这种综合症被认为是 风湿性疾病，与类风湿性关节炎有关， 系统性红斑狼疮 研讨会的组织将 从基础科学的进步（了解疾病的基本 水平，侧重于免疫遗传和自身免疫机制） 然后发展到医学上的具体临床问题， 牙科. 自身抗原基因的克隆， 淋巴因子和其他免疫调节因子， 将讨论病毒感染的作用。 我们的目标之一是 解决诊断分类的问题，因为许多患者 有重叠的临床症状， 近年来，特别是在 中枢神经系统症状 两个讲习班将讨论新的治疗形式和 干燥综合征的流行病学。 所有NIH的负责人 将邀请资助的多功能关节炎中心， 发展流行病学研究合作， 中心. 这次会议的信息涉及到 生长因子和淋巴细胞生物学也可能刺激未来 干燥综合征以来的肿瘤和癌变研究 是一种界面疾病，其中5-10%的患者 恶性淋巴组织增生

Funds are requested to support the Second International Symposium on Sjogren's Syndrome which will be held in Austin, Texas from October 23-25, 1988. This meeting is an opportunity for international authorities as well as many American rheumatologists to discuss a disease of great interest to biology, dentistry and medicine. The specific needs for this conference come out of the natural history of this multifactorial illness which has attracted considerable interest among basic medical and dental scientists as well as clinicians representing several different disciplines. The syndrome is considered one of the rheumatic diseases and is related to rheumatoid arthritis and systemic lupus erythematosus. The Symposium's organization will progress from basic science (understanding the disease at a basic level focusing on immunogenetic and autoimmune mechanisms) and then progress to specific clinical problems in medicine and dentistry. The cloning of autoantigen genes, the role of lymphokines and other immunoregulatory factors, and the possible role of virus infection will be discussed. One of our goals is to address the issue of diagnostic classification since many patients have overlapping clinical syndromes which have created considerable difficulties in recent years particularly with regard to central nervous system manifestations. Two workshops will deal with new forms of treatment and the epidemiology of Sjogren's Syndrome. The Directors of all NIH funded Multipurpose Arthritis Centers will be invited in hopes of developing an epidemiologic research collaboration between these centers. Information to come out of this meeting related to growth factors and lymphocyte biology may also stimulate future research in neoplasia and carcinogenesis since Sjogren's Syndrome is an interface disease in which 5-10% of patients develop malignant lymphoproliferation.