MRFASS MINORITIES RISK FACTORS AND STROKE STUDY

这个项目的目标是更好地了解中风的病因。 并找出我们的社会各阶层之间存在的差异 这些部分，以便中风预防计划可以设计为 少数民族人群应对潜在的、可改变的中风危险因素 在这些社区里。要检验的主要假设是： 非洲裔美国人和西班牙裔美国人中风风险增加 是由于中风的公认因素增加所致 主要是从对白人的研究中确定的。 根据过去两年的中风入院观察， 预计可从入院人员中招募750例突发中风病例 到这些设施的3.25年。在这些人中，150人是西班牙裔，225人 将是非裔美国人，375人将是白人。每一个西班牙裔和非洲人- 美国的案件将与同一案件的两个社区控制相匹配 种族，而白人将在一对一的基础上匹配。控制 将在社区组织的帮助下招募， 西奈半岛有一种持续的关系。有关中风风险的信息 因素包括高血压、糖尿病、吸烟、血脂、颈动脉 和心脏病，可通过面谈、采血、EKG和 超声检查。从这些数据来看，多元Logistic回归 将开发模型来估计相对风险和归因风险 与这些因素相关联的每一组。那么它将会是 有可能确定是否存在临床上重要的风险差异 这些群体中的因素配置。

The goal of this project is to better understand the etiology of stroke in all segments of our society and identify what differences exist between these segments so that programs for stroke prevention may be designed for minority populations addressing potent, modifiable risk factors for stroke in these communities. The primary hypothesis to be tested is: The increased risk of stroke in the African-American and Hispanic populations is due to an increased prevalence of recognized factors for stroke as determined primarily from studies of whites. Based on observations of stroke admissions during the past two years, it is anticipated that 750 incident stroke cases can be recruited from admissions to these facilities in 3.25 years. Of these, 150 will be Hispanic, 225 will be African-American and 375 will be white. Each Hispanic and African- American case will be matched with two neighborhood controls of the same ethnicity, while whites will be matched on a one-to-one basis. Controls will be recruited with the aid of community organizations with whom Mount Sinai has an ongoing relationship. Information regarding stroke risk factors, including hypertension, diabetes, smoking, serum lipids, carotid and cardiac disease, will be obtained by interview, blood sampling, EKG and ultrasound evaluations. From these data, multiple logistic regression models will be developed to estimate the relative and attributable risk associated with these factors for each of these groups. It will then be possible to determine if there are clinically important differences in risk factor configurations among these groups.