T cell regulation for intestinal barrier function

考虑到IEL与肠上皮细胞的密切关系，已知IEL对于调节肠屏障功能是重要的。肠道特定的微环境决定了IEL独特的细胞和分子特征，这些特征可能影响IEL的功能。我们发现CD101在IEL上高度表达。我们还发现，CD101的缺失导致肠道屏障破坏和细菌入侵增加，导致肠道炎症风险增加。我们感兴趣的是研究CD101如何控制IEL功能来调节肠道屏障功能的分子机制。

IELs are known to be important for regulating intestinal barrier function, considering their close association with intestinal epithelial cells. The specific microenvironment of intestine determines the unique cellular and molecular features of IELs which potentially impact IELs function. We found that CD101 is highly expressed on IELs. We also found the loss of CD101 causes disrupted intestinal barrier and elevated bacterial invasion, leading to increased risk of intestinal inflammation. We are interested in studying molecular mechanisms of how CD101 controls IELs function to regulate intestinal barrier function.