Epidemiologic Field Studies

BCDDP：乳腺癌检测示范项目跟踪研究(1030)这项研究跟踪了乳腺癌示范项目(BCDDP)的约60,000名前参与者。目前的分析包括：1)体重指数、激素替代治疗和乳腺癌风险；2)乳腺癌组织学类型的风险因素；3)根据乳腺癌ER/PR状况的风险因素；4)子宫切除状况和所有原因和原因的死亡率；5)饮酒与乳腺癌风险；5)涉及乳腺癌、结肠癌、卵巢癌和肾癌的饮食汇集项目分析；和8)DCEG汇集项目，包括非甾体抗炎药和膀胱癌风险。胃癌：山东临渠抑制胃癌前病变的随机多干预试验(446年)利用中国农村地区一项为期8年的试验数据，我们观察了长期补充维生素(C、E和Se)、大蒜以及一次性服用阿莫西林/奥美拉唑对一碳代谢循环中重要因素的影响。长期服用大蒜补充剂会使叶酸增加10%，长期服用维生素和硒补充剂会使谷胱甘肽增加13%。两种补充剂对维生素B12或同型半胱氨酸都没有显著影响，阿莫西林和奥美拉唑治疗对这些分析物中的任何一种都没有显著影响。炎症性乳腺癌(IBC)试点研究和病例对照研究(314)我们已经敲定了埃及、突尼斯和摩洛哥炎症性乳腺癌病例对照研究的方案、问卷、表格和研究程序，为2008年底的培训和数据收集做准备。这项研究将包括北非4个中心(突尼斯1个中心加上几个私人诊所，埃及2个，摩洛哥1个)在两年期间累积的大约400例IBC病例。两个对照组将包括：1)400例非IBC乳腺癌病例；2)400名来访者对照(不包括一级亲属)，随机选择在研究医院住院的女性患者(不包括患有乳腺癌、卵巢癌、子宫内膜癌和鼻咽癌的患者)。这项研究将涉及管理问卷、人体测量、唾液收集、IBC病例乳房的数字照片，以及在选定中心收集IBC病例和非IBC乳腺癌对照的石蜡包埋肿瘤组织。这项研究将作为一个联盟进行，表格的开发和翻译由美国国家癌症研究所协调。NCI-DCEG负责在埃及和突尼斯的研究中心制定研究程序。乳腺癌风险和乳腺癌血清库中乳腺增生性疾病与遗传基因变异的关系(1100)这项研究在过去一年中一直处于不活跃状态，涉及从1977至1987年间接受良性乳腺活检并参加密西西比州大急流城乳腺癌血清库队列研究的2636名绝经前妇女的随访。这项后续研究的具体目标包括：1)检索和编码与绝经前参与者在血清库中收到的良性乳腺疾病活检有关的初始病理报告；2)跟踪参与者并与全州癌症登记和NDI联系以确定乳腺癌病例；3)对在特定目标1(上文)中检索和编码后被发现患有良性乳腺疾病并被诊断为乳腺癌风险相当高的参与者进行基因分型，或者那些在特定目标2中追踪后被发现在后续行动中发展为乳腺癌的人，以及选定的匹配对照。每个具体目标的进展：1)在总共2632份病理报告中，有2184份是从大急流城的医院检索到的。病理报告收集现在被认为已经完成2)所有参与者以前都被提交给养恤金福利信息(PBI)以确定生命状况，而那些被推定活着的人被与TransUnion数据库进行匹配，以确认他们的社会安全号码(SSN)，那些被推定为已故的人被提交给国家死亡指数(NDI)加死因确定。与NDI和密歇根州癌症登记中心的匹配，加上最初的后续调查问卷的结果，产生了186名患有乳腺癌的独特女性。3)已经完成了针对特定目标的初步研究3.从12个样本中提取DNA，并由ATCC-Frederick合同实验室对两个基因变异进行基因分型。

BCDDP: Breast cancer detection demonstration project follow-up study (1030) This study follows about 60,000 former participants in the Breast Cancer Demonstration Project (BCDDP). Current analyses include: 1) body mass index, hormone replacement therapy and breast cancer risk; 2) risk factors for histologic types of breast cancer; 3) risk factors according to breast cancer ER/PR status; 4) hysterectomy status and all-cause and cause-specific mortality; 5) alcohol consumption and breast cancer risk; 5) dietary pooling project analyses involving cancers of the breast, colon, ovary, and kidney; and 8) DCEG pooling projects, including NSAIDS and bladder cancer risk. Gastric cancer: Randomized multi-intervention trial to inhibit precancerous gastric lesions in Linqu, Shandong Province (446) Using data from an 8-year trial in rural China, we looked at the effects of long-term vitamin (C, E, and selenium) and garlic supplementation and one time administration of amoxicillin/omeprazole on factors important in the one-carbon metabolic cycle. Long-term administration of garlic supplements increased folate by 10%, and long-term administration of the vitamin and selenium supplement increased glutathione by 13%. Neither supplement had a significant effect on vitamin B12 or homocysteine, and the treatment with amoxicillin and omeprazole had no significant effects on any of these analytes. Inflammatory breast cancer (IBC) pilot study and case-control study (314) We have finalized the protocol, questionnaire, forms, and study procedures for a case-control study of inflammatory breast cancer in Egypt, Tunisia, and Morocco in preparation for the training and start of data collection in late 2008. The study will include approximately 400 IBC cases accrued over a two-year period at 4 centers in North Africa (1 center in Tunisia plus several private clinics, 2 in Egypt, and 1 in Morocco). Two control groups will be included: 1) 400 non-IBC breast cancer cases and; 2) 400 visitor controls (excluding first-degree relatives) to randomly selected female inpatients (excluding those with breast, ovarian, endometrial, and nasopharyngeal cancer) in the study hospitals. The study will involve the administration of a questionnaire, anthropometric measurements, saliva collection, digital photographs of the breasts of IBC cases, and the collection of paraffin-embedded tumor tissue for IBC cases and non-IBC breast cancer controls at selected centers. The study will be conducted as a consortium, with forms development and translation coordinated at the National Cancer Institute-USA. The NCI-DCEG is responsible for developing study procedures at the study centers in Egypt and Tunisia. Risk of breast cancer and hyperplastic breast conditions in the breast cancer serum bank in relation to inherited genetic variants (1100) This study, which has been inactive for the past year, involves follow-up of 2636 premenopausal women who received a benign breast biopsy and were enrolled in the Breast Cancer Serum Bank cohort study in Grand Rapids, MI, from 1977 through 1987. The specific aims of this follow-up study include: 1) retrieval and coding of the initial pathology report pertaining to the benign breast disease biopsy received by premenopausal participants in the serum bank; 2) tracing of participants and linkage to statewide cancer registries and the NDI to identify breast cancer cases; 3) genotyping of participants who are found, after the retrieval and coding in Specific Aim 1 (above), to have benign breast disease diagnoses that confer a considerably elevated risk of breast cancer, or those who are found, after tracing in Specific Aim 2, to have developed breast cancer during follow-up, and selected matched controls. Progress on each specific aim: 1) 2184 out of a total of 2632 pathology reports being sought have been retrieved from hospitals in Grand Rapids. Pathology report collection is now considered completed 2) all participants had previously been submitted to Pension Benefit Information (PBI) for vital status determination, while those presumed living were matched against the TransUnion database to confirm their social security number (SSN), and those who were presumed deceased were submitted to the National Death Index (NDI) plus for cause of death determination. The match with the NDI and with the Michigan State Cancer Registry, together with results from the original follow-up questionnaires, yielded 186 unique women with breast cancer. 3) pilot studies have been completed for Specific Aim 3. DNA was extracted from 12 sample specimens and genotyped for two genetic variants by ATCC-Frederick contract laboratories.