NIDCD Core for Clinical Research and Care

NIDCD临床研究和护理核心支持了以下NIDCD项目： 1 Z01-DC-000016-15核因子-kappaB在影响人类沟通的肿瘤分子发病机制和治疗中的作用 1 Z01 DC000031-14人体神经功能成像研究 1 Z01 DC000039-12导致综合征性和非综合征性听力障碍的基因鉴定 1 Z01 DC000046-11人类通讯障碍的遗传学研究 1 Z01 DC000057-10脑成像与建模 1 Z01 DC000060-08遗传性耳聋的分子分析 1 Z01 DC000064-08听力平衡障碍临床分析 头颈癌中1个Z01-DC-000073信号和转录因子网络的相互作用 头颈癌的1个Z01-DC-000074基因组和蛋白质组学研究 核心支持的NIDCD协议包括： T-DC-0005注意力测量方法的研究 Oh93-DC-0016-非综合征遗传性耳聋基因图谱：印度/巴基斯坦方案 92-DC-0178-言语运动控制和语言处理的功能神经成像研究 97-DC-0057-口吃的非参数和参数链接研究 97-DC-0180-遗传性耳聋的遗传分析 00-DC-0073-遗传性听觉处理缺陷的鉴定 00-DC-0176-调音性耳聋的遗传学研究 01-DC-0099-NIDCD头颈外科分会临床研究方案评价 01-C-0104-头颈部复发性或转移性鳞癌患者联合应用茶酶前体抑制剂PS-341和放射治疗的I期研究。 01-DC-0228-前庭导水管扩大所致听力损害的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 01-DC-0230-味觉缺陷研究 02-DC-0008-使用C-11雷氯普利和PET评估发育性口吃突触前和突触后的多巴胺功能 05-DC-0238-睡眠剥夺和恢复睡眠对言语、语言和其他高级认知功能的影响：一项脑电-功能磁共振联合研究 06-DC-0218-耳鸣的神经模型和脑成像 08-C-0071-波特兹米布和西妥昔单抗联合或联合顺铂治疗晚期头颈癌的I期研究 NIDCD临床研究和护理核心在2008财年支持了2986项门诊评估，比前一年增加了10%。其中听力科1211人次，普通耳鼻喉科797人次，急诊234人次，耳科373人次，头颈187人次，遗传学35人次，语音语音门诊20人次。耳鼻咽喉科核心医师完成了70例大手术，并在高级临床助理期间指导了5名医学生。

The NIDCD Core for Clinical Research and Care supported the following NIDCD projects: 1 Z01-DC-000016-15 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 Z01 DC000031-14 Functional Neuroimaging Studies in Humans 1 Z01 DC000039-12 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 Z01 DC000046-11 Genetic Studies of Human Communications Disorders 1 Z01 DC000057-10 Brain Imaging And Modeling 1 Z01 DC000060-08 Molecular Analysis Of Human Hereditary Deafness 1 Z01 DC000064-08 Clinical Analysis Of Disorders Of Hearing And Balance 1 Z01-DC-000073 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 Z01-DC-000074 Genomics and Proteomics of Head and Neck Cancer The NIDCD protocols supported by the core include: T-DC-0005 Studies of Measures of Attention Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 92-DC-0178 - Functional Neuroimaging Studies of Speech Motor Control and Language Processing 97-DC-0057 - Non-parametric and parametric Linkage Studies of Stuttering 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 00-DC-0073- Identification of Hereditary Auditory Processing Defiicts 00-DC-0176 - Genetic Studies of Tune Deafness 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-C-0104 - A Phase I Study of Concomitant Therapy with Preoteasome Inhibitor PS-341 and Radiation in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 01-DC-0230 - Studies in the Deficits in the Sense of Taste 02-DC-0008 - Assessment of pre- and post-synaptic dopamine function in developmental stuttering using C-11 raclopride and PET 05-DC-0238 - Effects of Sleep Deprivation and Recovery Sleep on Speech, Language and Other Higher Cognitive Functions: A Combined EEG-fMRI Study 06-DC-0218 - Neural Modeling and Brain Imaging of Tinnitus 08-C-0071 - Phase I Study of Bortezmib and Cetuximab without or with Cisplatin with Radiation therapy for Patients with Advanced Head and Neck Cancer The NIDCD Core for Clinical Research and Care in FY08 supported 2,986 outpatient clinic evaluations, a 10% increase over the prior year. These included 1,211 Audiology, 797 General Otolaryngology, 234 Urgent, 373 Otology, 187 Head and Neck, 35 Genetics and 20 Voice and Speech clinic visits. Core otolaryngologists performed 70 major surgical cases, and mentored 5 medical students during senior clinical clerkships.