Workshop on Multi-Scale Muscle Mechanics

描述（由申请人提供）：正常运作的骨骼肌是人体健康的重要组成部分。骨骼肌的宏观行为由源自广泛空间尺度的机械特性的整合决定，从收缩蛋白的结构和行为开始，延伸到多个肌肉和关节在正常和病理改变的运动期间相互作用的方式。要理解这种复杂性，就需要综合这些层面的发现。但是，虽然个别社会会议可能会考虑这种行为的特定方面，我们不知道一个单一的会议，考虑了所有这些。因此，我们正在组织2009年多尺度肌肉力学研讨会，以提供一个论坛，其中肌肉力学功能的许多方面可以详细讨论，首先作为孤立的问题，然后作为整个问题的综合检查的一部分。研讨会的科学目标包括：1）讨论骨骼肌力学在健康和疾病方面的历史发展、当前知识和未来研究; 2）讨论正在推进或有潜力推进肌肉功能知识的技术进步; 3）强调研究肌肉力学的综合方法;以及4）讨论如何整合和综合在不同尺度上进行的分析的结果。这些目标将在研讨会的科学计划中得到解决，其中将包括关于肌肉蛋白质，肌肉纤维，整个肌肉，肌肉肌腱单位和多肌肉/多关节系统的机械特性的研讨会，如实验和计算建模方法所揭示的那样。该研讨会将提供两个针对开始研究生和经验丰富的肌肉生物力学高层次的演示教程。此外，还将邀请全体会议演讲，并根据提供的摘要进行口头和海报介绍。会议议程的一个独特之处是组成讨论小组，在整个会议过程中详细研究具体问题，然后在最后向整个小组报告。此外，我们的目标是促进有前途的年轻科学家的教育，并加强他们与既定的研究人员的互动。因此，我们还将提供以学生为导向的节目，如海报行走图尔斯之旅，职业发展小组讨论和辅导计划。在这份申请中，我们要求提供支持，以降低受训人员的注册费，并为代表性不足的少数群体学生和女学生提供旅行津贴方案。我们的最终目标是向科学界和非科学界传播会议的结果，因此我们将以电子方式提供会议记录。 公共卫生相关性：叙述骨骼肌的正常功能对身体健康至关重要。在2009年多尺度肌肉力学研讨会上，我们将提供一个论坛，在这个论坛上，肌肉力学功能的许多方面可以详细讨论，首先是孤立的问题，然后是全面的。我们还将通过提供面向学生的编程，辅导计划和旅行津贴计划，为未来的肌肉科学家的教育做出贡献。

DESCRIPTION (provided by applicant): Properly functioning skeletal muscle is a vital component of human health. Skeletal muscles' macroscopic behaviors are determined by the integration of mechanical properties that originate at widely ranging spatial scales, beginning with the structures and behaviors of the contractile proteins and extending through to the manner in which multiple muscles and joints interact during normal and pathologically altered motion. Understanding this complexity requires synthesizing the findings from these many levels. But while individual society meetings may consider particular aspects of this behavior, we are not aware of a single meeting that has considered all of them. Therefore, we are organizing the 2009 Workshop on Multi-scale Muscle Mechanics in order to provide a forum in which many aspects of muscle mechanical function can be discussed in detail, first as isolated questions and then as part of integrative examination of the entire problem. The workshop's scientific objectives include: 1) to discuss the historical development, current knowledge, and future research on skeletal muscle mechanics, in health and disease; 2) to discuss technological advances that are advancing or have the potential to advance knowledge of muscle function; 3) to emphasize an integrative approach in studying muscle mechanics; and 4) to discuss how to integrate and synthesize findings from analyses performed at different scales. These objectives will be addressed in the workshop's scientific program, which will include symposia about the mechanical properties of muscle proteins, muscle fibers, whole muscles, muscle-tendon units, and multi-muscle/multi-joint systems, as uncovered by experimental and computational modeling approaches. The symposia will provide both tutorial presentations targeted to beginning graduate students and high-level presentations for experienced muscle biomechanists. In addition, there will be invited plenary lectures and oral and poster presentations from proffered abstracts. A unique aspect of the meeting agenda is the formation of discussion groups that will examine specific questions in detail over the course of the entire conference, and then report back to the whole group at the end. In addition, we aim to promote the education of promising young scientists and enhance their interactions with established investigators. Therefore, we will also provide student-oriented programming, such as poster walking tours, a career development panel discussion, and a mentoring program. In this application, we request support to reduce the registration fee for trainees and to provide a travel stipend program for students from under-represented minority groups and for female students. Our final objective is to disseminate the meeting's findings to the scientific and lay communities, and so we will make the conference proceedings publically available. PUBLIC HEALTH RELEVANCE: Narrative The proper function of skeletal muscles is essential to good health. In the 2009 Workshop on Multi-Scale Muscle Mechanics, we will provide a forum in which many aspects of muscle mechanical function can be discussed in detail, first as isolated questions and then comprehensively. We will also contribute to the education of future muscle scientists by providing student-oriented programming, a mentoring program, and a travel stipend program.