Common-Path OCT for Real Time Imaging in Minimally Invasive Neurosurgery

描述（由申请人提供）：我们提议开发一种功能成像和传感系统，该系统结合了共路傅立叶域OCT和血氧定量法，用于辅助神经外科手术。我们计划开发这项技术，以提高内窥镜神经外科手术，针脑活检和解剖靶定位的安全性和有效性。该亚专业需要非常精确和精细地操纵手术工具穿过周围关键组织的紧密空间。因此，提供真实的时间术中成像和血氧定量感测信息具有很高的潜在价值，所述信息指示关键解剖结构的位置，所述关键解剖结构诸如正常脑-肿瘤界面、皮质脊髓束和肿瘤衍生的和正常的血管。为了实现这一目标，该系统将具有内窥镜微光纤传感器，该传感器可以与现有的神经外科工具完全集成，并且可以测量相对于手术工具的组织边界、周围组织的血氧水平，以及识别组织体积内的血管。我们将使用动物模型和人体尸体标本来评估该系统在神经外科中的性能。我们提出的方法在几个方面是新颖的。首先，这代表了使用共光路OCT获得脑结构和病理性脑异常（体内肿瘤模型）的内窥镜成像的首次研究。其次，这是第一个与神经外科工具集成的共路内窥镜传感器，希望有助于引导内窥镜工具，并提供关键组织避免。第三，我们将提供用于神经外科应用的共光路OCT实施手术工具的首次评价。公共卫生相关性：拟议的工作旨在通过在手术过程中为外科医生提供实时关键解剖结构信息来解决和提高与内窥镜神经外科手术相关的安全性。

DESCRIPTION (provided by applicant): We propose to develop functional imaging and sensing system combining common-path Fourier-Domain OCT with oxymetry for assisting in neurosurgery. We plan to develop this technology to enhance the safety and efficacy of endoscopic neurosurgery, needle brain biopsies, and anatomical target localization. This subspecialty requires very precise and delicate manipulation of surgical tools through tight spaces with surrounding critical tissues. Therefore, there is high potential value with providing real time intra-operative imaging and oxymetry sensing information which indicates the location of critical anatomical structures such as normal brain-tumor interface, corticospinal tract, and blood vessels, both tumor derived and normal. In order to achieve this objective, the system will have endoscopic micro-optical-fiber sensor that can be fully integrated with existing neurosurgical tools and can measure tissue boundaries relative to surgical tools, blood oxygenation level of surrounding tissues, and identify blood vessels within the tissue volume. We will evaluate the performance of this system for neurosurgery using animal models and human cadaveric specimens. Our proposed approach is novel in several ways. First, this represents the first study of use of a common-path OCT to obtain endoscopic imaging of brain structures and pathological brain abnormalities (in vivo tumor model). Second, this is the first common-path endoscopic sensor integrated with neurosurgical tools in hopes of help guiding endoscopic tools and provides critical tissue avoidance. Third, we will provide first evaluation of the common-path OCT implemented surgical tool for neurosurgery applications. PUBLIC HEALTH RELEVANCE: The proposed work is designed to address and enhance the safety associated with endoscopic neurosurgery by providing surgeons with real-time critical anatomical structure information during surgery.