San Antonio STI TM CRC

描述（由申请人提供）：圣安东尼奥STI TM CRC提案代表了一项综合、协作和创新的多学科研究工作，旨在调查和预防重要的性传播疾病新出现的原因。它将基础和临床策略与行为和流行病学分析、统计/计算和行政核心支持结合起来，重点关注服务不足的南德克萨斯州少数族裔妇女（墨西哥裔和非裔美国人）及其男性伴侣。女性参与者参加一个专门的诊所（指定的项目SAFE），该诊所完全由圣安东尼奥STI TM CRC监督，为研究患者提供临床评估和体检，收集和分发生殖道和血液样本到特定项目，并作为招募，访谈和干预活动的收集中心。目标患者群体既未得到充分研究，又不成比例地受到性传播感染的影响。CRC的目标是开发和测试策略和工具，以了解特定性传播感染的生物学和感染潜力，并通过疫苗、诊断、杀微生物剂、行为和临床特征和干预措施来预防和控制疾病进展。圣安东尼奥中心以其与圣安东尼奥STI TM CRC研究人员之间的密切合作以及与其他CRC中心和行业合作伙伴的额外联盟而闻名。沙眼衣原体、阴道毛滴虫和生殖支原体是重点关注的性传播感染病原体，尽管与其他性传播感染和泌尿生殖器感染的相关性通过项目和核心重叠和合作进行了研究。圣安东尼奥CRC的一个特殊优势是主要研究人员之间存在的长期工作关系，这种关系已经持续多年，集中在圣安东尼奥德克萨斯大学健康科学中心的微生物学和免疫学以及妇产科学部门。如STI TM CRC申请中所述，这些项目是1：新型衣原体候选疫苗；2：阴道毛滴虫的黏膜/口腔抗体诊断；3：生殖支原体的持久性和诊断；4：少数民族夫妇性传播感染双重预防干预措施；5：性传播疾病的临床方面。这些项目由统计/计算和行政核心提供支持。

DESCRIPTION (provided by applicant): The San Antonio STI TM CRC proposal represents an integrative, collaborative and innovative multi-disciplinary research effort to investigate and prevent important emerging causes of sexually transmitted diseases. It combines basic and clinical strategies with behavioral and epidemiological analyses and statistical/computing and administrative core support and focuses on underserved South Texas minority women (Mexican- and African-American) and their male partners. The women participants attend a dedicated clinic (designated Project SAFE), which is totally overseen by the San Antonio STI TM CRC and provides clinical evaluation and physical examination of study patients, collects and distributes genital tract and blood samples to specific projects and serves as the collection center for recruitment, interview and intervention activities. The targeted patient population is both understudied and disproportionately affected by STIs. The CRC's goals are to develop and test strategies and tools to understand the biology and infectious potential of specific STIs and prevent and control disease progression through vaccine, diagnostic, microbicide, behavioral and clinical characterizations and interventions. The San Antonio CRC is distinguished by very close collaborations among San Antonio STI TM CRC investigators and additional alliances with other CRC centers and industrial partners. Chlamydia trachomatis, Trichomonas vaginalis, and Mycoplasma genitalium are the emphasized STI agents although correlations with other STIs and urogenital infections are examined through project and core overlap and collaborations. A special strength of the San Antonio CRC is the long-term working relationships that exist among the key investigators, which have been ongoing for many years and are centered in the Departments of Microbiology and Immunology and Obstetrics and Gynecology of The University of Texas Health Science Center at San Antonio. As detailed in the STI TM CRC application the projects are 1: Novel Chlamydia Vaccine Candidates; 2: Mucosal/Oral Antibody Diagnosis for Trichomonas vaginalis; 3: Mycoplasma genitalium Persistence and Diagnosis; 4: Dual STI Prevention Interventions for Minority Couples; and 5: Clinical Aspects of STDs in Dyads. These projects are supported by Statistical/Computing and Administrative Cores.