Nutrient dependent signalling in bone via calcium sensing receptors

骨质疏松症是一个主要的健康问题，影响着多达10%的澳大利亚社区，每年花费卫生预算数百万美元。众所周知，许多关键的营养因素，包括钙和饮食蛋白质摄入量，在骨质疏松症的发生发展中起着重要作用。这项提议将检验一种假设，即人类骨骼细胞表达一种蛋白质，这种蛋白质可以感知钙和氨基酸(钙感应受体)，从而对血浆中存在的钙离子和氨基酸产生的营养信号做出反应。此外，我们认为，钙感应受体通过促进成骨细胞的增殖、成熟和存活，是饮食中钙和蛋白质促进骨形成的关键分子机制。这些研究有可能解释提高局部钙浓度的bpne吸收活性与骨形成活性和骨形成与吸收活性之间的耦合关系。这些研究有可能解释钙和蛋白质摄入对骨量的积极影响，也可能有助于阐明成骨细胞和破骨细胞活动之间的偶联调节。

Osteoporosis is a major health problem that affects as many as 10% of the Australian Community and costs the health budget millions of dollars each year. A number of key nutritional factors including calcium and dietary protein intake are known to be important in the development of osteoporosis. This proposal will test the hypothesis that human bone cells express a protein which senses calcium and amino acids, the calcium-sensing receptor, and thereby respond to nuritional signals arising from the presence of calcium ions and amino acids in plasma. Furthermore, we propose that by promoting osteoblast proliferation, maturation and survival, the calcium sensing receptor acts as the key molecular mechanism by which dietary calcium and protein promotes bone formation.These studies have potential to explain relationships between bpne resorptive activity, which raises local calcium concentrations, and bone formation activity and the coupling of bone forming and resorbing activity. These studies have the potential to explain the positive effects of calcium and protein intake on bone mass and may also shed light on the regulation of the coupling between osteoblastic and osteoclastic activity