Core Center

描述（由申请人提供）：核心中心的总体目标与以前一样：汇集17名研究听力和沟通障碍不同方面的研究人员，提高他们个人努力和正在进行的合作的效率和生产力，将研究动物基本听力机制的研究人员与研究人类听力障碍的研究人员结合起来。这为创造性和发展合作取得成果提供了新的、有时是独特的机会。参与该应用程序的研究人员代表了广泛的听力科学，从昆虫的听力解剖学和生理学到听力受损人类复杂声音感知的心理声学。现有的项目包括蝙蝠和鸟类的声音定位、昆虫和蝙蝠的捕食相互作用、鱼类和鸟类的毛细胞再生、鸟类毛细胞再生后听力和发声的恢复、人类语言过程的MIG成像、蝙蝠、鸟类、正常人、听力受损者和老年人的时间分辨率精度，以及昆虫、鱼类、鸟类和人类复杂声学感知的个体发生。总的来说，这组研究人员和听力科学的主题可能是现存的最多样化的。P30机制的支持对于保持高水平的交互式完整性和生产力至关重要。

DESCRIPTION (provided by applicant): The overall goals of the Core Center remain as before to: bring together 17 investigators working on different aspects of hearing and communication disorders, increase the efficiency and productivity of their individual efforts and ongoing collaborations, integrate investigators studying basic hearing mechanisms in animals with investigators studying human hearing impairment. This provides new and sometimes unique opportunities for creative and developing collaborations to reach fruition. The investigators participating in this application represent a broad range of hearing science from anatomy and physiology of hearing in insects to the psychoacoustics of complex sound perception in hearing impaired humans. Existing projects include sound localization in bats and birds, prey-predator interactions in insects and bats, hair cell regeneration in fish and birds, recovery of hearing and vocalizations in birds following hair cell regeneration, MIG imaging of language processes in humans, precision of time resolution in bats, birds, normal, hearing impaired, and aged humans, and the ontogeny of complex acoustic perception in insects, fish, birds, and humans. Taken together, this group of investigators and topics in hearing science is probably the most diverse in existence. The support of the P30 mechanism is essential in keeping a high level of interactive integrity and productivity. Core 1 Imaging Core Director: Arthur N. Popper, Ph.D. Description (provided by applicant): The Imaging Core is designed to enhance and broaden Core member's abilities to use state-of-the-art imaging facilities at the University of Maryland. The Core will take advantage not only of the current facility in the Laboratory for Biological Ultrastructure (LBU) to carry out transmission electron, scanning electron, and confocal microscopy and for tissue preparation, but also a new EM facility with very high-end TEM's and a new 2-photon confocal microscopy facility. However, despite having outstanding facilities for our investigators, there is limited assistance available to users of the various imaging facilities, and no training or consultation is routinely provided. Central to the Core's strategy is hiring a doctoral-level support person whose primary responsibility will be to enhance the research efforts in the Core faculty's labs by introducing new imaging techniques and innovative uses of established techniques. The support person will be supervised by the Core Director (Popper) and a Steering Committee consisting of the Core Director and the directors of the imaging facilities being used by our investigators. This Core will provide advanced capabilities to the labs already using imaging as a main component of their research and will encourage and assist other less frequent users in becoming more effective users of imaging technology. This will ultimately lead to new collaborative research efforts that would not otherwise be possible, or even imagined (e.g., comparing hair cell ontogeny in fish and birds). Because of the unique constellations of users involved, a particularly innovative use of this Core is the porting of invertebrate techniques to vertebrates and vice versa.